Stroke treatment upgrade: adding a Clot-Buster after clot removal may boost recovery
NCT ID NCT07687056
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This trial tests whether giving a clot-busting drug directly into the brain arteries after mechanical clot removal can improve recovery in people having a severe stroke. About 1,500 adults with acute ischemic stroke who undergo endovascular thrombectomy will be randomly assigned to receive either the extra drug or standard care alone. The study measures how independent participants are 90 days later, aiming to see if the added treatment reduces long-term disability.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tenecteplase or Alteplase (clot-busting drugs)
- What this could lead to
- If successful, this approach could become a standard addition to stroke treatment, helping more people recover with less disability after a severe stroke.
- What could go wrong
- This is a large phase 3 trial, but the added drug may increase bleeding risk in the brain. The benefit may be small or not apply to all stroke patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHUM -Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada
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CIUSSS de l'Estrie - CHUS Fleurimont Hôpital (Sherbrooke)
Sherbrooke, Quebec, Canada
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Health Sciences North Horizon Sante-Nord
Greater Sudbury, Ontario, Canada
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Kelowna Regional Hospital
Kelowna, British Columbia, Canada
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Ottawa Civic Hospital
Ottawa, Ontario, Canada
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Royal Columbian Hospital
New Westminster, British Columbia, Canada
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Royal University Hospital
Saskatoon, Saskatchewan, Canada
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Sunnybrook Health Science Centre
Toronto, Ontario, Canada
Contact Email: •••••@•••••
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The George Institute for Global Health
Sydney, Barangaroo, NSW 2000, Australia
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University of Alberta
Edmonton, Alberta, Canada
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University of British Columbia
Vancouver, British Columbia, Canada
Contact Email: •••••@•••••
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University of Calgary- Foothills Medical Centre
Calgary, Alberta, T2N2T9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Manitoba - Winnipeg Health Science Centre
Winnipeg, Manitoba, Canada
Contact Email: •••••@•••••
Contact
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