New hope for mild stroke: Clot-Buster may help when time is lost

NCT ID NCT07476898

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a clot-dissolving drug called tenecteplase works better than standard antiplatelet pills for people who have a mild but disabling stroke caused by a large blocked artery. About 864 adults who arrive at the hospital 4.5 to 24 hours after symptoms start will be randomly assigned to receive either the drug or dual antiplatelet therapy. The main goal is to see if more patients recover with little or no disability after 90 days.

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Conditions

The condition(s) this trial relates to.

ischemic stroke large artery stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Anshan Central Hospital

    Anshan, Liaoning, 114001, China

    Contact Phone: •••-•••-••••

  • Anshan Changda Hospital

    Anshan, Liaoning, 114005, China

    Contact Phone: •••-•••-••••

  • Benxi Central Hospital

    Benxi, Liaoning, 117000, China

    Contact Phone: •••-•••-••••

  • Central Hospital Affiliated to Shenyang Medical College

    Shenyang, Liaoning, 110024, China

    Contact Phone: •••-•••-••••

  • Chaoyang Central Hospital

    Chaoyang, Liaoning, 122000, China

    Contact Phone: •••-•••-••••

  • Dalian Municipal Central Hospital Affiliated of Dalian University of Technology

    Dalian, Liaoning, 116033, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Dandong Central Hospital

    Dandong, Liaoning, 118000, China

    Contact Phone: •••-•••-••••

  • Dandong First Hospital

    Dandong, Liaoning, 118000, China

    Contact Phone: •••-•••-••••

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian, 350001, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Fushun Central Hospital

    Fushun, Liaoning, 113006, China

    Contact Phone: •••-•••-••••

  • Fuxin People's Hospital

    Fuxin, Liaoning, 123000, China

    Contact Phone: •••-•••-••••

  • Huludao Central Hospital

    Huludao, Liaoning, 125000, China

    Contact Phone: •••-•••-••••

  • Liaojian Group Fukuang General Hospital

    Fushun, Liaoning, 113008, China

    Contact Phone: •••-•••-••••

  • Liaojian Group Tieling Coal General Hospital

    Tieling, Liaoning, 112700, China

    Contact Phone: •••-•••-••••

  • Liaoning Provincial People's Hospital

    Shenyang, Liaoning, 110016, China

    Contact Phone: •••-•••-••••

  • Liaoyang Central Hospital

    Liaoyang, Liaoning, 111000, China

    Contact Phone: •••-•••-••••

  • Panjin Central Hospital

    Panjin, Liaoning, 124010, China

    Contact Phone: •••-•••-••••

  • Shenyang Fifth People's Hospital

    Shenyang, Liaoning, 110023, China

    Contact Phone: •••-•••-••••

  • Shenyang First People's Hospital

    Shenyang, Liaoning, 110041, China

    Contact Phone: •••-•••-••••

  • Shenyang Fourth People's Hospital

    Shenyang, Liaoning, 110031, China

  • Shenyang Tenth People's Hospital

    Shenyang, Liaoning, 110044, China

  • Sujiatun District Central Hospital

    Shenyang, Liaoning, 110101, China

    Contact Phone: •••-•••-••••

  • The First Affiliated Hospital of Jinzhou Medical University

    Jinzhou, Liaoning, 121001, China

    Contact Phone: •••-•••-••••

  • The Fourth Affiliated Hospital of China Medical University

    Shenyang, Liaoning, 110032, China

    Contact Phone: •••-•••-••••

  • The Second Affiliated Hospital of Shenyang Medical College

    Shenyang, Liaoning, 110002, China

    Contact Phone: •••-•••-••••

  • Tieling Central Hospital

    Tieling, Liaoning, 112000, China

    Contact Phone: •••-•••-••••

  • Tieling County Central Hospital

    Tieling, Liaoning, 112600, China

    Contact Phone: •••-•••-••••

  • Wafangdian Central Hospital

    Wafangdian, Liaoning, 116300, China

    Contact Phone: •••-•••-••••

  • Wafangdian Third People's Hospital

    Wafangdian, Liaoning, 116300, China

    Contact Phone: •••-•••-••••

  • Yingkou Central Hospital

    Yingkou, Liaoning, 115000, China

    Contact Phone: •••-•••-••••