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New combo treatment could help more Large-Stroke patients walk again

NCT ID NCT07603440

Not yet recruiting Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a clot-busting drug called tenecteplase before a mechanical clot removal procedure helps people with large ischemic strokes recover better than the procedure alone. About 486 adults with large-vessel occlusion strokes will be randomly assigned to one of two groups. The main goal is to see if more patients can walk independently three months after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Tenecteplase (a clot-busting drug given as a single injection)
What this could lead to
If it works, this could show that adding tenecteplase before clot removal helps more people with large strokes recover enough to walk independently.
What could go wrong
This is a phase 3 trial, but it's still early and the benefit of tenecteplase in large-core strokes is unproven. There is a risk of bleeding in the brain, though tenecteplase may be safer than older drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain infarction brain ischemia cerebral infarction cerebrovascular disorder Ischemic Stroke large artery stroke stroke disorder vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STROKE

Contacts and locations

Locations

  • AP-HM - Hôpital de la Timone

    Marseille, 13005, France

  • AP-HP - Hôpital Bichat

    Paris, 75018, France

  • AP-HP - Hôpital Bicêtre

    Le Kremlin-Bicêtre, 94275, France

  • AP-HP - Hôpital Henri Mondor-Albert Chenevier

    Créteil, 94000, France

  • AP-HP - Hôpital Lariboisiere-Fernand Widal

    Paris, 75010, France

  • CH Gonesse

    Gonesse, 95500, France

  • CH Pays d'Aix - Site d'Aix-en-Provence

    Aix-en-Provence, 13100, France

  • CH Perpignan

    Perpignan, 66046, France

  • CH Saint-Denis - Hôpital Delafontaine

    Saint-Denis, 93200, France

  • CH Sud Francilien

    Corbeil-Essonnes, 91106, France

  • CH Versailles - Hôpital André Mignot

    Le Chesnay, 78000, France

  • CHRU Nancy - Hôpital Central

    Nancy, 54035, France

  • CHRU Tours - Hôpital Bretonneau

    Tours, 37000, France

  • CHU Besançon

    Besançon, 25030, France

  • CHU Bordeaux - Groupe Hospitalier Pellegrin

    Bordeaux, 33076, France

  • CHU Brest - Hôpital de la Cavale Blanche

    Brest, 29609, France

  • CHU Caen Normandie

    Caen, 14000, France

  • CHU Dijon Bourgogne

    Dijon, 21079, France

  • CHU Grenoble Alpes - Site Nord

    Grenoble, 38043, France

  • CHU Lille - Hôpital Roger Salengro

    Lille, 59000, France

  • CHU Limoges - Hôpital Dupuytren

    Limoges, 87042, France

  • CHU Montpellier - Hôpital Saint-Eloi

    Montpellier, 34295, France

  • CHU Nantes - Hôpital Nord Laennec

    Nantes, 44093, France

  • CHU Nice - Hôpital Pasteur

    Nice, 6000, France

  • CHU Poitiers - Hôpital de La Milétrie

    Poitiers, 86000, France

  • CHU Reims - Hôpital Maison Blanche

    Reims, 51100, France

  • CHU Rennes - Hôpital Pontchaillou

    Rennes, 35033, France

  • CHU Rouen - Hôpital Charles-Nicolle

    Rouen, 76031, France

  • CHU Saint-Etienne - Hôpital Nord

    Saint-Etienne, 42055, France

  • Fondation Adolphe de Rothschild

    Paris, 75019, France

  • GH Paris Saint-Joseph - Hôpital Paris Saint-Joseph

    Paris, 75014, France

  • GHU Paris Psychiatrie et Neurosciences - Hôpital Sainte-Anne

    Paris, 75014, France

  • HCL - Hôpital Pierre Wertheimer

    Bron, 69500, France

  • Hôpital Foch

    Suresnes, 92150, France

  • Hôpital Pitié-Salpêtrière

    Paris, 75013, France

  • Hôpitaux universitaires de Strasbourg - Hôpital de Hautepierre

    Strasbourg, 67098, France

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