Could a tiny dose of a blood thinner cut stroke risk in seniors?
NCT ID NCT07454707
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a very low dose (15 mg) of the blood thinner edoxaban to standard aspirin or clopidogrel can prevent repeat strokes in people aged 75 and older who have already had an ischemic stroke. About 1,200 participants will be randomly assigned to receive either the combination or standard antiplatelet therapy alone, and will be followed for 2 to 4 years. The goal is to see if the combination reduces stroke risk without causing dangerous bleeding.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Edoxaban 15 mg (a blood thinner) added to standard antiplatelet therapy (aspirin or clopidogrel)
What this could lead to
If it works, this could offer a new, safer way to prevent repeat strokes in older adults by combining a low-dose blood thinner with standard anti-clotting medication.
What could go wrong
This is a large phase 3 trial, but the low-dose edoxaban has not been tested in stroke patients without atrial fibrillation. Adding a blood thinner always raises the risk of serious bleeding, which could outweigh the benefits.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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