Magnetic pulses to the brain may help stroke survivors regain arm function

NCT ID NCT07691099

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS), combined with paired associative stimulation (PAS), can improve arm and hand movement in people who have had a stroke. The trial includes 40 adults who experienced their first ischemic stroke within the past three weeks and have arm weakness. Participants receive either active or sham stimulation over both motor areas of the brain for 15 sessions over three weeks, and their motor function is tracked for up to a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
deep transcranial magnetic stimulation (dTMS) with paired associative stimulation
What this could lead to
If successful, this approach could offer a non-invasive way to improve arm and hand function after a stroke, potentially speeding recovery.
What could go wrong
This is a small early-stage trial with only 40 participants, so results may not apply to all stroke survivors. The treatment may not lead to meaningful improvement over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Nov 2019

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The diagnosis of stroke is based on computed tomography (CT) or magnetic resonance imaging (MRI). * The diagnosis of first acute ischemic stroke in unilateral hemisphere within 3 weeks after onset. * Clinically evident arm hemiparesis attributable to acute ischemic stroke. * Age of 18-85 years. * The ability to sign a informed consent. Exclusion Criteria: * Any previous stroke. * Minor stroke with non-disabling deficit or rapidly improving neurological symptoms. * Prior participation in the present study, or planned participation in another therapeutic trial, prior to the final assessment in this trial. * Current participation in another study with an investigational drug or device. * Women known to be pregnant, lactating or having a positive or indeterminate pregnancy test. * Any intracranial surgery, intraspinal surgery, or serious head trauma (any head injury that required hospitalization) within the past 3 months prior to participation in the current study. * Presence or history of intracranial neoplasm (except small meningiomas) or arteriovenous malformation. * Intracranial aneurysm, unless surgically or endovascularlytreated more than 3 months prior to participation in the current study. * Seizure at the onset of stroke or a history of epilepsy. * Life expectancy less than 3 months. * Cardiac pacemakers, implanted medication pumps, intracardiac lines, or acute, unstable cardiac disease. * Other serious illness, e.g., severe hepatic, cardiac, or renal failure. * Acute myocardial infarction or complex disease that may confound treatment assessment. * Cognitive or verbal impairment that prevented understanding of or cooperation with the research study. Under the following medical conditions, treatment was stopped, and patients were excluded from the study: * Acute worsening of \> 4 points on the NIH stroke scale (NIHSS). * Acute symptoms of headache nausea and vomiting suggestive of possible sICH. * Occurrence of seizures. * Appearance of a new ventricular arrhythmia, tachycardia, fibrillation etc. or a new life-threatening supraventricular arrhythmia (e.g., rapid atrial fibrillation or supraventricular tachycardia). * Symptomatic bradycardia - heart rate less than 50 beats per min.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Soroke University Medical Center

    Beersheba, Israel

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