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Nerve block injection may ease migraine drug withdrawal

NCT ID NCT07568496

Not yet recruiting Symptom relief Sponsor: Mahidol University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a nerve block injection at the back of the head can help people with migraine who overuse painkillers. The injection contains lidocaine and a steroid. 130 participants will receive either the active injection or a placebo. Researchers will track headache days and medication use for 3 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
lidocaine and methylprednisolone injection
What this could lead to
If it works, this could provide a safe, short-term treatment to help migraine sufferers stop overusing painkillers without severe withdrawal headaches.
What could go wrong
This is an early-stage trial with no phase, and the nerve block may not work better than a placebo. Risks include allergic reactions or injection-site pain.

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Conditions

The condition(s) this trial relates to.

Headache Disorders, Secondary migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GREATER OCCIPITAL NERVE BLOCK MEDICATION OVERUSE HEADACHE MIGRAINE DISORDERS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Faculty of Medicine Siriraj Hospital, Mahidol University

    Bangkok, Bangkok, 10700, Thailand

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Faculty of Medicine, Chiang Mai University

    Chiang Mai, Chiang Mai, 50200, Thailand

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Faculty of Medicine, Prince of Songkla University

    Hat Yai, Changwat Songkhla, 90110, Thailand

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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