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Can High-Repetition or High-Intensity training boost walking after stroke?

NCT ID NCT07725211

Disease control Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether adding either high-repetition task-oriented training or high-intensity gait training to standard neurodevelopmental therapy helps people with chronic stroke walk farther and move more easily. Forty-five participants who had a stroke at least six months ago will be randomly assigned to one of three groups for eight weeks of therapy. The study aims to see which approach, if any, leads to greater improvements in walking capacity and functional mobility.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-repetition task-oriented training and high-intensity gait training, added to neurodevelopmental treatment
What this could lead to
If one approach proves superior, it could point toward more effective rehabilitation strategies for regaining walking ability after stroke.
What could go wrong
This is a small, early-phase trial with only 45 participants, so results may not apply broadly. The improvements may be modest and not translate to real-world mobility.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of first-ever unilateral stroke (ischemic or hemorrhagic) confirmed by clinical and/or radiological findings * Time since stroke onset of at least 6 months (chronic phase) * Age between 18 and 75 years * Ability to walk at least 10 meters independently, with or without an assistive device * Functional Ambulation Category (FAC) score of 3 or higher * Sufficient cognitive ability to understand and follow instructions (Mini-Mental State Examination score ≥ 24) * Willingness to participate and provision of written informed consent Exclusion Criteria: * Recurrent stroke or bilateral hemispheric involvement * Unstable cardiovascular disease or other medical conditions contraindicating high-intensity exercise * Severe lower extremity spasticity interfering with gait training (Modified Ashworth Scale score \> 3) * Orthopedic, rheumatological, or other neurological conditions affecting gait * Severe visual or vestibular impairment * Severe aphasia or cognitive impairment preventing participation in training or assessments * Participation in another structured rehabilitation or exercise program during the study period * Botulinum toxin injection to the lower extremity within the last 6 months

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Conditions

The condition(s) this trial relates to.

hemiplegia stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic stroke Hemiplegia Stroke

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Bingol State Hospital - City: Bingöl, Country: Türkiye (listede "Turkey" olarak geçebilir), Zip: 12000

    Bingoel, Center, 12000, Turkey (Türkiye)

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