Eye ultrasound may reveal best drug to shield brain during aneurysm surgery

NCT ID NCT07660861

Not yet recruiting Knowledge-focused Sponsor: Fatih Sultan Mehmet Training and Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether remifentanil or esmolol is better at preventing dangerous pressure spikes in the brain when a breathing tube is inserted. Patients with unruptured brain aneurysms scheduled for coil embolization will receive one of the two drugs before intubation. Researchers will use an eye ultrasound to measure changes in brain pressure, aiming to find the safest approach.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Remifentanil and Esmolol
What this could lead to: If one drug works better, it could become the preferred choice to protect the brain during intubation for aneurysm patients.
What could go wrong: This is a small, early-stage study measuring a surrogate marker (eye ultrasound) rather than direct brain outcomes, so results may not translate to better patient recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain aneurysm intracranial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CEREBRAL ANEURYSM UNRUPTURED INTRACRANIAL PRESSURE

Contacts and locations

Locations

Fatih Sultan Mehmet Training and Research Hospital

Istanbul, Istanbul, 34752, Turkey (Türkiye)

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