Brain-wave test may predict who wakes up after severe brain injury

NCT ID NCT07736820

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

After a severe brain injury, some patients survive but cannot communicate, and it is difficult to predict who will recover consciousness. This observational study in Cyprus is testing whether a brain-wave monitoring technique called the bispectral index (BIS) can improve predictions beyond standard bedside exams. Researchers will follow 40 patients with traumatic brain injury or haemorrhagic stroke for 6 to 12 months to see how well BIS readings correlate with later recovery of consciousness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to better tools for predicting which patients with severe brain injury will regain consciousness, helping families and doctors make more informed decisions.
What could go wrong
This is a small, single-centre observational study, not a treatment trial. It is designed only to estimate effect sizes for a future larger study, so its findings may not be conclusive on their own.

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Conditions

The condition(s) this trial relates to.

akinetic mutism Brain Injuries, Traumatic Coma Consciousness Disorders intracerebral hemorrhage Persistent Vegetative State subarachnoid hemorrhage traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Nicosia General Hospital, Department of Neurosurgery

    Nicosia, 2029, Cyprus

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