Brain scans may reveal why some stroke survivors walk better after exercise

NCT ID NCT07663292

Not yet recruiting Knowledge-focused Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates why some chronic stroke survivors with slow walking speed improve after high-intensity interval training (HIIT) while others do not. Participants will undergo 12 weeks of supervised cycling sessions, along with MRI brain scans and walking tests before and after the program. The goal is to find brain-based markers that predict who will respond to exercise therapy, potentially leading to more personalized rehabilitation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: high-intensity interval training (HIIT) cycling
What this could lead to: If successful, this could help doctors predict which stroke survivors will benefit most from exercise therapy, personalizing rehab.
What could go wrong: This is an early-stage observational study with only 55 participants. It may not identify clear brain markers, and results may not apply to all stroke survivors.

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STROKE SUBCORTICAL LESIONS

Contacts and locations

Locations

Emory Rehabilitation Hospital

Atlanta, Georgia, 30322, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States

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