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Why do stroke survivors get so tired? scientists look inside the brain

NCT ID NCT07594938

Knowledge-focused Sponsor: Vrije Universiteit Brussel Source: ClinicalTrials.gov ↗

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The trial has finished. Results may not be published yet.
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Cancelled before anyone took part.

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Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study aims to understand how neuromuscular fatigue develops in stroke survivors compared to healthy individuals. Researchers will measure brain activity (EEG) and muscle activity (EMG) in 120 participants while they perform repeated leg exercises until fatigue. The goal is to identify whether fatigue after stroke is due to changes in the brain, the muscles, or the communication between them.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help design better rehabilitation programs for stroke survivors by targeting the root causes of fatigue.
What could go wrong
This is an early observational study, not a treatment trial. It may not lead to direct clinical changes, and results might not apply to all stroke survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Oct 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Stroke survivors will be recruited from Brussels University Hospital (Brussels, Belgium). Healthy, age-matched controls will be recruited through our research group's network and residential care homes in Belgium.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Stroke survivors will be recruited from Brussels University Hospital (Brussels, Belgium). Patients who have a first-ever stroke, ≥18 years, subacute phase: 1 week to 6 months post-stroke, quadriceps (hemiplegic side) strength ≤3/5 (Medical Research Council (MRC)), and Montreal Cognitive Assessment (MoCA) ≥21 will be included. Exclusion Criteria: Exclusion criteria include a history of a previous stroke, severe spasticity (Modified Ashworth Scale (MAS) 3-4 in quadriceps/hamstrings), other neurological, motor, musculoskeletal, or orthopedic conditions affecting trunk stability and lower limb mobility, non-cerebral strokes (e.g., brainstem, cerebellar), or dementia (MoCA ≤20), and current or former athletes. Athletes are defined as individuals who participated in organized competitive sports and engaged in structured training ≥3 sessions per week for ≥1 year within the 5 years preceding stroke. Control participants will be excluded if they meet the same exclusion criteria.

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Conditions

The condition(s) this trial relates to.

Fatigue hemorrhagic stroke ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebro-vascular accident Hemorrhage stroke Ischemia stroke Stroke

How to take part

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  1. The official record

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