Blood thinners for stroke survivors with a history of brain bleeding: a delicate balance
NCT ID NCT07609654
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a blood thinner or the current standard care (which may include antiplatelet drugs or no blood thinners). The goal is to see which approach better prevents another stroke without causing another brain bleed over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Direct Oral Anticoagulants (DOACs) such as apixaban, rivaroxaban, edoxaban, or dabigatran
What this could lead to
If successful, this could provide clear guidance on whether blood thinners are safe and effective for preventing strokes in patients with both atrial fibrillation and a history of brain bleeding.
What could go wrong
This is a Phase 4 trial, but the population is very high-risk and the balance between preventing clots and causing bleeds is delicate. The results may not apply to all patients, and there is a real risk of recurrent brain bleeding.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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