Blood thinners for stroke survivors with a history of brain bleeding: a delicate balance

NCT ID NCT07609654

Not yet recruiting Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a blood thinner or the current standard care (which may include antiplatelet drugs or no blood thinners). The goal is to see which approach better prevents another stroke without causing another brain bleed over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Direct Oral Anticoagulants (DOACs) such as apixaban, rivaroxaban, edoxaban, or dabigatran
What this could lead to: If successful, this could provide clear guidance on whether blood thinners are safe and effective for preventing strokes in patients with both atrial fibrillation and a history of brain bleeding.
What could go wrong: This is a Phase 4 trial, but the population is very high-risk and the balance between preventing clots and causing bleeds is delicate. The results may not apply to all patients, and there is a real risk of recurrent brain bleeding.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation intracerebral hemorrhage ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE ATRIAL FIBRILLATION (AF) INTRACEREBRAL HEMORRHAGE

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