INTRACEREBRAL HEMORRHAGE

This study tests whether the drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). High blood pressure can make the bleeding worse, so getting it under control fast is critical. The trial will compare clevidi…

This study tests whether using a special bladder catheter that continuously measures body temperature can help guide treatment and improve recovery in people with severe brain bleeding. About 318 participants will be randomly assigned to either continuous bladder temperature moni…

This study tests whether a structured care bundle—including rapid blood pressure control, reversal of blood thinners, and management of fever and blood sugar—can improve outcomes for people with a brain bleed. About 3500 adults in Sweden and Australia will receive either the care…

This study compares two medicines—apixaban (a blood thinner) and aspirin—in people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents future strokes or death. About 700 pa…

This pilot study tests whether high-dose vitamin D can help the body clear blood clots in the brain after a hemorrhagic stroke. Forty adults with a recent brain bleed will receive either vitamin D or standard care. Researchers will measure how fast the blood clot shrinks and chec…

This study compares two approaches for treating moderate brain hemorrhages: AI-assisted minimally invasive surgery to remove the clot versus standard medical care. About 680 patients will be randomly assigned to one of the two groups. The goal is to see which method leads to bett…

This study tests whether the antibiotic minocycline can help people recover better after a spontaneous brain bleed (intracerebral hemorrhage). About 1,200 adults who had a bleed within the last 48 hours will receive either minocycline or a placebo for a short time. The goal is to…

This Phase 3 trial is testing whether people who have a brain hemorrhage (bleeding stroke) should continue or stop taking their statin medication. The study will follow 1,456 participants for years to see which strategy leads to fewer repeat bleeds or other serious events. It als…

This Phase 3 trial tests whether a clotting drug called recombinant factor VIIa can improve outcomes for people having a hemorrhagic stroke (bleeding in the brain). The drug is given within 2 hours of stroke onset. The study will enroll 350 adults aged 18-80. Half get the drug, h…

This study tests whether a non-invasive ultrasound device can safely help clear blood clots in the brain after a hemorrhagic stroke. About 86 adults with small-to-moderate brain bleeds will receive either standard care plus ultrasound or standard care alone. The main goal is to s…

This study looks at people with an irregular heartbeat (atrial fibrillation) who have had a brain bleed. Doctors are unsure if blood thinners are safe for them. The trial compares two options: the blood thinner apixaban or a procedure to close a part of the heart (left atrial app…

This study looks at 200 people who had a bleeding stroke caused by high blood pressure. Doctors want to know if starting blood thinners (heparin) early—within 2 days—or waiting until day 3 is safer and better at preventing blood clots in the legs or lungs. Participants get brain …

This study tests whether a scoring tool (TRICH score) can help doctors decide which patients who had a bleeding stroke should start three blood pressure medicines right away. The goal is to quickly lower blood pressure and reduce the risk of another stroke. About 140 adults in Ho…

This study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps pat…

This study tests whether the drug tranexamic acid can prevent brain bleed expansion in people with a type of stroke called intracerebral hemorrhage. The researchers are using new criteria to select patients most likely to benefit, based on bleed location and size. About 70 adults…

This study tests whether a device that gently stimulates a nerve in the ear can help people recovering from a brain bleed. The device is placed on the left ear and delivers mild electrical pulses for 30 minutes, twice a day, for 10 days. Researchers will measure brain swelling an…

This study tests whether a dedicated care protocol for non-traumatic brain hemorrhage can reduce death and disability. Researchers will track 600 patients admitted to a French hospital, comparing outcomes before and after the protocol is introduced. The goal is to see if early, e…

This study tests if a mobile health app can help people who had a bleeding stroke better control their blood pressure. About 140 participants will use the app to track their numbers and get health tips. The goal is to see if the app helps more people reach safe blood pressure lev…

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study tests a new way to check for bleeding after stroke surgery using a special ultrasound through a clear skull implant. It aims to see if this method is as accurate as a CT scan, which is the current standard but is expensive and time-consuming. About 25 adults who had a …

This study uses blood samples from over 1,100 people to create artificial clots in the lab, mimicking brain hemorrhages. Researchers test a modified clot-busting drug (rtPA) to find the best dose for different bleeding risks. The goal is to improve clot removal and guide future t…

This study tests a new set of procedures called the HI-SPEED Protocol, designed to help hospitals evaluate stroke patients faster and decide who needs to be transferred for advanced care. The goal is to reduce the time patients spend in the first hospital before being moved to a …

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This study tests two new Siemens imaging prototypes during minimally invasive surgery to remove brain bleeds. The tools aim to detect leftover bleeding and measure blood flow in the brain. Researchers will compare the prototype images with standard CT scans to see if they are use…

This study looks at 1000 adults with brain hemorrhage to see if the shape of the blood clot (hematoma) early on can predict whether the bleeding will get worse. Researchers will also compare different treatments to find the best approach. The goal is to improve recovery and reduc…

This study looks at how heart function relates to recovery in people with severe traumatic brain injury or brain bleeding. Researchers will collect data from routine monitoring and follow up with 50 adults 6 months after hospital discharge. The goal is to better understand the co…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study looks at whether giving antibiotics for just 24 hours around the time of placing a special antibiotic-coated brain drain works as well as giving them for the whole time the drain is in place. The goal is to find the best way to prevent serious brain infections in peopl…

This study is testing whether a non-invasive ultrasound scan, combined with artificial intelligence (AI), can quickly identify bleeding in the brain (intracerebral hemorrhage) in people having a stroke. Researchers will enroll 500 adults with acute stroke and perform a standard C…

This pilot study will test whether a stellate ganglion nerve block—a procedure used for chronic pain—can improve blood flow in the tiny vessels of the eye. Researchers will use a special camera (OCTA) to scan the retinas of 50 adults before and after the block. The goal is to see…

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

This study looks at whether waking patients with brain bleeding every hour for checks (standard care) versus every two hours affects their confusion and long-term thinking. Researchers will track 120 adults in the ICU for delirium and later cognitive function. The goal is to see …

This study follows 500 adults who had a brain hemorrhage and received surgery to remove the blood clot. Researchers will track their recovery and quality of life over time to see which surgical methods and timings lead to the best outcomes. The goal is to gather information that …