Can a blood thinner prevent strokes in brain bleed survivors?

NCT ID NCT03907046

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two medicines—apixaban (a blood thinner) and aspirin—in people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents future strokes or death. About 700 participants will be randomly assigned to take either apixaban or aspirin for up to several years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Apixaban (Eliquis) and aspirin
What this could lead to: If apixaban works better than aspirin, it could become the preferred treatment to prevent strokes in people who have had a brain bleed and have atrial fibrillation.
What could go wrong: This is a large phase 3 trial, but results may not apply to all patients. Apixaban could increase the risk of another brain bleed, and the benefit over aspirin is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atrial fibrillation intracerebral hemorrhage stroke disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION INTRACEREBRAL HEMORRHAGE

Contacts and locations

Locations

Abbott Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Albany Medical Center
RECRUITING

Albany, New York, 12208, United States
Arrowhead Regional Medical Center
RECRUITING

Colton, California, 92324, United States
Ascension Sacred Heart Pensacola
RECRUITING

Pensacola, Florida, 32504, United States
Ascension St. John Medical Center
RECRUITING

Tulsa, Oklahoma, 74104, United States
Augusta University Medical Center
RECRUITING

Augusta, Georgia, 30912, United States
Avera Research Institute
RECRUITING

Sioux Falls, South Dakota, 57108, United States
Banner University Medical Center
RECRUITING

Tucson, Arizona, 85719, United States
Baptist Health Lexington
RECRUITING

Lexington, Kentucky, 40503, United States
Barnes Jewish Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Baylor College of Medicine Medical Center
WITHDRAWN

Houston, Texas, 77030, United States
Baystate Medical Center
RECRUITING

Springfield, Massachusetts, 01199, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Bon Secours St. Mary's Hospital
RECRUITING

Richmond, Virginia, 23226, United States
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Broward Health Medical Center
RECRUITING

Fort Lauderdale, Florida, 33316, United States
Buffalo General Medical Center
ACTIVE_NOT_RECRUITING

Buffalo, New York, 14202, United States
Burke Rehabilitation Center
RECRUITING

White Plains, New York, 10605, United States
Capital Health Regional Medical Center
WITHDRAWN

Trenton, New Jersey, 08638, United States
Carolinas Medical Center
WITHDRAWN

Charlotte, North Carolina, 28204, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Central DuPage Hospital
RECRUITING

Winfield, Illinois, 60190, United States
Chandler Regional Medical Center
WITHDRAWN

Chandler, Arizona, 85224, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic Akron General
RECRUITING

Akron, Ohio, 44307, United States
Cleveland Clinic Tradition Hospital
RECRUITING

Port Saint Lucie, Florida, 34987, United States
Community Regional Medical Center of Fresno
RECRUITING

Fresno, California, 93720, United States
Cooperman Barnabas Medical Center
RECRUITING

Livingston, New Jersey, 07052, United States
Cox Medical Center South
RECRUITING

Springfield, Missouri, 65807, United States
Danbury Hospital
SUSPENDED

Danbury, Connecticut, 06810, United States
Desert Regional Medical Center
RECRUITING

Palm Springs, California, 92262, United States
Doctors Medical Center Modesto, Modesto, CA
RECRUITING

Modesto, California, 95350, United States
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
ECU Health Medical Center
RECRUITING

Greenville, North Carolina, 27834, United States
Eastern Maine Medical Center
WITHDRAWN

Bangor, Maine, 04401, United States
Eden Medical Center, Castro Valley
WITHDRAWN

Castro Valley, California, 94546, United States
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
Erlanger Health System
WITHDRAWN

Chattanooga, Tennessee, 37403, United States
Evanston Hospital
RECRUITING

Evanston, Illinois, 60201, United States
Forsyth Medical Center
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Fort Sanders Regional Medical Center
RECRUITING

Knoxville, Tennessee, 37916, United States
Froedtert Hospital
WITHDRAWN

Milwaukee, Wisconsin, 53226, United States
Geisinger Medical Center
WITHDRAWN

Danville, Pennsylvania, 17822, United States
George Washington University Hospital
RECRUITING

Washington D.C., District of Columbia, 20037, United States
Good Samaritan Hospital
RECRUITING

Cincinnati, Ohio, 45220, United States
Grady Memorial Hospital
RECRUITING

Atlanta, Georgia, 30303, United States
Greenville Hospital System
RECRUITING

Greenville, South Carolina, 29605, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Harborview Medical Center
RECRUITING

Seattle, Washington, 98104, United States
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06102, United States
HealthPartners Methodist Hospital
ACTIVE_NOT_RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Henry Ford Hospital
WITHDRAWN

Detroit, Michigan, 48202, United States
Hoag Hospital Newport Beach
WITHDRAWN

Newport Beach, California, 92663, United States
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Huntington Memorial Hospital
WITHDRAWN

Pasadena, California, 91105, United States
IU Health Methodist Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
Inova Fairfax Hospital
RECRUITING

Falls Church, Virginia, 22042, United States
J.W. Ruby Memorial Hospital
RECRUITING

Morgantown, West Virginia, 26506, United States
JFK Medical Center
RECRUITING

Edison, New Jersey, 08820, United States
Jackson Memorial Hospital
RECRUITING

Miami, Florida, 33136, United States
Javon Bea Hospital - Riverside
WITHDRAWN

Rockford, Illinois, 61114, United States
Jefferson Abington Hospital
RECRUITING

Abington, Pennsylvania, 19001, United States
Jersey Shore University Medical Center
RECRUITING

Neptune City, New Jersey, 07753, United States
Kaiser Permanente Fontana Medical Center
RECRUITING

Fontana, California, 92335, United States
Kaiser Permanente Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90027, United States
Kaiser Permanente Redwood City Medical Center, Redwood City, CA
RECRUITING

Redwood City, California, 94063, United States
Kaiser Permanente Sacramento Medical Center
RECRUITING

Sacramento, California, 95825, United States
Kings County Hospital Center
RECRUITING

Brooklyn, New York, 11203, United States
Lahey Hospital & Medical Center
RECRUITING

Burlington, Massachusetts, 01805, United States
Lehigh Valley Hospital - Cedar Crest
WITHDRAWN

Allentown, Pennsylvania, 18103, United States
Long Beach Memorial Medical Center
WITHDRAWN

Long Beach, California, 90806, United States
Los Alamitos Medical Center
RECRUITING

Los Alamitos, California, 90720, United States
Loyola University Medical Center
RECRUITING

Maywood, Illinois, 60153, United States
M Health Fairview University of Minnesota Medical Center
RECRUITING

Minneapolis, Minnesota, 55455, United States
Maimonides Medical Center
TERMINATED

Brooklyn, New York, 11219, United States
Maine Medical Center
RECRUITING

Portland, Maine, 04102, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
TERMINATED

Jacksonville, Florida, 32224, United States
McLaren Flint
WITHDRAWN

Flint, Michigan, 48532, United States
McLaren Macomb
TERMINATED

Mount Clemens, Michigan, 48043, United States
MedStar Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20007, United States
MedStar Washington Hospital Center
WITHDRAWN

Washington D.C., District of Columbia, 20010, United States
Medical University of South Carolina University Hospital
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Hermann Texas Medical Center
RECRUITING

Houston, Texas, 77030, United States
Mercy Hospital Oklahoma City
RECRUITING

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States
Mercy Hospital St. Louis
RECRUITING

St Louis, Missouri, 63141, United States
Mercy San Juan Medical Center
RECRUITING

Carmichael, California, 95608, United States
Methodist University Hospital
RECRUITING

Memphis, Tennessee, 38104, United States
Metro Health Hospital
WITHDRAWN

Wyoming, Michigan, 49519, United States
MetroHealth Medical Center
RECRUITING

Cleveland, Ohio, 44109, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Morton Plant Hospital
RECRUITING

Clearwater, Florida, 33756, United States
Moses H. Cone Memorial Hospital
RECRUITING

Greensboro, North Carolina, 27401, United States
Mount Sinai West
RECRUITING

New York, New York, 10019, United States
Munson Medical Center
RECRUITING

Traverse City, Michigan, 49684, United States
NCH Hospital, Arlington Heights
RECRUITING

Arlington Heights, Illinois, 60005, United States
NYC Health + Hospitals/Elmhurst
RECRUITING

Elmhurst, New York, 11373, United States
NYP Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
NYP Weill Cornell Medical Center
RECRUITING

New York, New York, 10065, United States
NYU Langone Hospital - Brooklyn
RECRUITING

Brooklyn, New York, 11220, United States
New Hanover Regional Medical Center
RECRUITING

Wilmington, Delaware, 28403, United States
New Hanover Regional Medical Center
RECRUITING

Wilmington, North Carolina, 28403, United States
NewYork-Presbyterian Brooklyn Methodist Hospital
WITHDRAWN

Brooklyn, New York, 11215, United States
North Shore University Hospital
RECRUITING

Manhasset, New York, 11030, United States
OSF St. Francis Medical Center
RECRUITING

Peoria, Illinois, 61637, United States
OSU Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
OU Medical Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Ochsner Medical Center - Main Campus
RECRUITING

New Orleans, Louisiana, 70121, United States
Oregon Health & Science University Hospital
RECRUITING

Portland, Oregon, 92739, United States
Overlook Medical Center
RECRUITING

Summit, New Jersey, 07901, United States
PIH Health Hospital - Whittier
RECRUITING

Whittier, California, 90602, United States
PeaceHealth Sacred Heart Medical Center - RiverBend
RECRUITING

Springfield, Oregon, 97477, United States
Penn State Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Presbyterian Medical Center
RECRUITING

Charlotte, North Carolina, 28204, United States
Providence St. Vincent Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Rancho Los Amigos National Rehabilitation Center
SUSPENDED

Downey, California, 90242, United States
Regions Hospital
TERMINATED

Saint Paul, Minnesota, 55101, United States
Rhode Island Hospital
TERMINATED

Providence, Rhode Island, 02903, United States
Riverside Methodist Hospital
RECRUITING

Columbus, Ohio, 43214, United States
Ronald Reagan UCLA Medical Center
RECRUITING

Los Angeles, California, 90095, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
SUNY Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
Saint Alphonsus Regional Medical Center - Boise
RECRUITING

Boise, Idaho, 83706, United States
San Francisco General Hospital
RECRUITING

San Francisco, California, 94110, United States
Santa Barbara Cottage Hospital
RECRUITING

Santa Barbara, California, 93105, United States
Semmes Murphey Main Campus
RECRUITING

Memphis, Tennessee, 38120, United States
St. Cloud Hospital
RECRUITING

Saint Cloud, Minnesota, 56303, United States
St. David's Medical Center
WITHDRAWN

Austin, Texas, 78705, United States
St. John Medical Center
RECRUITING

Tulsa, Oklahoma, 74104, United States
St. John's Hospital
WITHDRAWN

Springfield, Illinois, 62769, United States
St. Joseph's Hospital
RECRUITING

Tampa, Florida, 33607, United States
St. Joseph's Hospital and Medical Center
WITHDRAWN

Phoenix, Arizona, 85013, United States
St. Jude Medical Center
RECRUITING

Fullerton, California, 92835, United States
St. Mary's Medical Center
WITHDRAWN

Grand Junction, Colorado, 81501, United States
Stanford University Medical Center
RECRUITING

Stanford, California, 94304, United States
Staten Island University Hospital - North Campus
WITHDRAWN

Staten Island, New York, 10305, United States
Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States
Strong Memorial Hospital
RECRUITING

Rochester, New York, 14642, United States
Swedish Medical Center - Cherry Hill Campus
WITHDRAWN

Seattle, Washington, 98122, United States
Tampa General Hospital
RECRUITING

Tampa, Florida, 33606, United States
Temple University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
The Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
The Queen's Medical Center
RECRUITING

Honolulu, Hawaii, 96813, United States
The University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
Thomas Jefferson University Hospital
WITHDRAWN

Philadelphia, Pennsylvania, 19107, United States
Trinity Health Saint Mary's
WITHDRAWN

Grand Rapids, Michigan, 49503, United States
Trinity Health Saint Mary's
RECRUITING

Grand Rapids, Michigan, 49503, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
UAMS Medical Center
WITHDRAWN

Little Rock, Arkansas, 77205, United States
UC Davis Medical Center
RECRUITING

Sacramento, California, 95817, United States
UC Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
UF Health Jacksonville
RECRUITING

Jacksonville, Florida, 32209, United States
UH Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
UMass Memorial Medical Center
RECRUITING

Worcester, Massachusetts, 01655, United States
UPMC Presbyterian Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UT Southwestern Medical Center
WITHDRAWN

Dallas, Texas, 75390, United States
UVA Medical Center
RECRUITING

Charlottesville, Virginia, 22908, United States
United Hospital, St. Paul
WITHDRAWN

Saint Paul, Minnesota, 55102, United States
University of Alabama Hospital
RECRUITING

Birmingham, Alabama, 35294, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
University of Illinois Hospital
RECRUITING

Chicago, Illinois, 60612, United States
University of Iowa Medical Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Hospital
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kentucky Hospital
RECRUITING

Lexington, Kentucky, 40536, United States
University of Louisville Hospital
RECRUITING

Louisville, Kentucky, 40202, United States
University of Michigan University Hospital
WITHDRAWN

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center
WITHDRAWN

Jackson, Mississippi, 39216, United States
University of Missouri Health Care
RECRUITING

Columbia, Missouri, 65212, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68105, United States
University of New Mexico Hospital
SUSPENDED

Albuquerque, New Mexico, 87106, United States
University of North Carolina Medical Center
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of South Alabama University Hospital
RECRUITING

Mobile, Alabama, 36604, United States
University of Texas Health Science Center San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
University of Utah Healthcare
RECRUITING

Salt Lake City, Utah, 84112, United States
VCU Medical Center
SUSPENDED

Richmond, Virginia, 23298, United States
Vanderbilt University Hospital
RECRUITING

Nashville, Tennessee, 37232, United States
Vassar Brothers Medical Center
TERMINATED

Poughkeepsie, New York, 12601, United States
Virginia Mason Medical Center
WITHDRAWN

Seattle, Washington, 98101, United States
Wake Forest Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
WellStar Kennestone Hospital
RECRUITING

Marietta, Georgia, 30060, United States
Westchester Medical Center
RECRUITING

Valhalla, New York, 10595, United States
Yale New Haven Hospital
RECRUITING

New Haven, Connecticut, 06511, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.