INTRACEREBRAL HEMORRHAGE

This study tests whether the antibiotic minocycline can improve recovery in people who have had a brain bleed (intracerebral hemorrhage). About 1,200 adults aged 18 to 80 will receive either minocycline or a placebo within 48 hours of their stroke. The goal is to see if the drug …

This study tests whether the drug tranexamic acid can stop bleeding from getting worse in people who have had a brain hemorrhage (a type of stroke caused by bleeding). The drug is given within 6 hours of the stroke. The study includes 70 adults with a specific amount of bleeding …

This study tests whether a minimally invasive surgery done soon after a hemorrhagic stroke can improve recovery. The surgery uses a small tube to drain the blood clot and deliver clot-dissolving medicine. The trial will compare this approach to standard medical care in 750 adults…

This study tests whether a non-invasive ultrasound device can safely help clear blood clots in the brain after a hemorrhagic stroke. About 86 adults with small-to-medium sized brain bleeds will receive either standard care alone or standard care plus daily ultrasound sessions. Th…

This study looks at 300 adults with atrial fibrillation (an irregular heartbeat) who have had a brain bleed. It compares three approaches to prevent future strokes: restarting blood thinners, using a device to close a part of the heart (left atrial appendage closure), or avoiding…

This study compares two blood thinners, apixaban and aspirin, in 700 people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents another stroke or death. Participants will t…

This study looks at whether people who had a brain bleed (intracerebral hemorrhage) should keep taking statins or stop them. It involves 1,456 adults aged 50 and older who were on statins before their bleed. The goal is to see which approach lowers the risk of another bleed and o…

This study tests a drug called recombinant factor VIIa (rFVIIa) for people having a bleeding stroke (intracerebral hemorrhage). The drug is given within 2 hours of symptoms to try to stop the bleeding and improve recovery at 90 days. About 350 adults aged 18-80 are being enrolled…

This study tests whether the IV drug clevidipine can lower blood pressure quickly and keep it stable in people having a bleeding stroke. About 1,000 adults with high blood pressure and a recent intracerebral hemorrhage will receive either clevidipine or another IV blood pressure …

This study tests whether a mobile health app can help people who have had a bleeding stroke (intracerebral hemorrhage) manage their high blood pressure. About 140 participants will use the app to track and control their blood pressure at home. The goal is to see if the app helps …

This study tests if a mild electrical stimulation on the ear (taVNS) can reduce dangerous brain swelling after a hemorrhagic stroke. 186 adults with a recent brain bleed will receive either real or fake stimulation. The main goal is to measure swelling reduction and check for sid…

This study tests whether giving a triple blood pressure pill soon after a brain bleed (intracerebral hemorrhage) helps control blood pressure better than usual care. It includes 140 adults in Hong Kong who are at high risk based on a special score. The goal is to lower the chance…

This study tests whether a simple set of treatments—lowering blood pressure, controlling fever, and managing blood sugar—can help people recover better after a brain bleed (intracerebral hemorrhage). About 3,500 adults in Sweden and Australia will receive either the care bundle o…

This study tests whether using AI to guide a minimally invasive procedure to remove blood from the brain leads to better recovery than medication alone. It involves 680 adults with a moderate-sized brain hemorrhage (20-50 mL) who are treated within 24 hours. The main goal is to s…

This study looks at the best time to start blood thinners (heparin) in people who have had a brain bleed due to high blood pressure. The goal is to prevent dangerous blood clots in the legs or lungs without causing more bleeding in the brain. About 200 participants will be random…

This pilot study tests whether high-dose vitamin D can help the body clear blood clots in the brain after a hemorrhagic stroke. Researchers will enroll 40 adults who had a brain bleed within the last 4 days. Half will get vitamin D pills for 6 months, and the other half will rece…

This study looks at how the heart works in people with severe traumatic brain injury or bleeding in the brain. Researchers will collect heart and brain monitoring data that is already part of routine care. They will follow up with participants 6 months after leaving the hospital …

This study looks at whether giving antibiotics for the entire time a brain drain (EVD) is in place prevents infections better than just a single dose before placement. About 84 adults with certain brain conditions will take part. The goal is to find out if longer antibiotic use i…

This study looks at whether a special care plan can help people who have a brain bleed (not from an injury). Brain bleeds are a serious type of stroke that can cause death or long-term disability. The study will track 600 adults to see if using a dedicated protocol in the hospita…

This study is tracking 8,000 stroke survivors to understand why some develop memory and thinking problems (dementia) after a stroke. Researchers will use brain scans, blood tests, and thinking assessments to find factors that predict cognitive decline. The goal is to help doctors…

This study aims to develop a non-invasive way to measure pressure inside the skull (intracranial pressure or ICP), which is currently done by drilling a hole in the head. Researchers will collect data from 581 patients who already have the standard surgical monitor, while also us…

This study looks at whether combining ultrasound with artificial intelligence can help doctors quickly identify bleeding strokes. About 500 adults with stroke symptoms will get a non-invasive ultrasound scan within 48 hours. Researchers will compare the AI's reading of the ultras…

This study looks at whether doing neurological checks every 2 hours instead of every hour in the ICU can reduce confusion (delirium) and long-term memory problems in older adults with a brain bleed. About 120 participants will be randomly assigned to one of two check frequencies.…

This study tests two new Siemens imaging prototypes during minimally invasive surgery for brain hemorrhage. The goal is to see if these tools can better detect leftover bleeding after the procedure. About 15 adults having this surgery at Mount Sinai West Hospital will participate…

This study follows 500 adults who had surgery for a brain hemorrhage to see how they recover over time. Researchers will track their ability to function and quality of life after different types of surgery. The goal is to learn which surgical approaches lead to the best outcomes,…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and remove medications from the body too quickly. It focuses on adults in the intensive care unit with life-threatening brain problems like stroke, severe injury, or infection.…

This study is testing whether a quick, painless eye scan called OCTA can spot signs of brain diseases like stroke and bleeding. Researchers will compare scans from 50 people with brain conditions and healthy volunteers. The goal is to gather early data to support larger studies, …

This study looks at how a nerve block (stellate ganglion block) changes blood flow in the tiny vessels of the eye. Researchers will use a special eye scan to measure these changes in 50 adults who are already receiving the nerve block for pain. The goal is to better understand ho…