Could a clotting protein be the first treatment for bleeding stroke?

NCT ID NCT07227246

Recruiting now Disease control Sponsor: Joseph Broderick, MD Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether a clotting drug called recombinant factor VIIa can improve outcomes for people having a hemorrhagic stroke (bleeding in the brain). The drug is given within 2 hours of stroke onset. The study will enroll 350 adults aged 18-80. Half get the drug, half get a placebo, plus standard care. The goal is to see if the drug reduces bleeding and leads to better recovery at 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Recombinant factor VIIa (a clotting protein)
What this could lead to: If successful, this could become the first approved treatment for acute hemorrhagic stroke, potentially reducing disability and death.
What could go wrong: This is an early-stage Phase 3 trial with 350 participants. The drug may not improve outcomes or could cause clotting complications. Results may not apply to all stroke patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intracerebral hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRACEREBRAL HEMORRHAGE

Contacts and locations

Locations

Arnau de Vilanova University Hospital
RECRUITING

Lleida, Catalonia, 25198, Spain
Barnes Jewish Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Bellvitge University Hospital,
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Central DuPage Hospital
RECRUITING

Winfield, Illinois, 60190, United States
Charite University Medicine Berlin
RECRUITING

Berlin, Germany
Clinic Frankfurt Hoechst
RECRUITING

Frankfurt am Main, Hesse, Germany
Gifu University Hospital
RECRUITING

Gifu, Japan
Girona University Hospital
RECRUITING

Girona, Catalonia, 17007, Spain
Grady Memorial Hospital
RECRUITING

Atlanta, Georgia, 30303, United States
Hamilton General Hospital
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Health Sciences Centre Winnipeg
RECRUITING

Winnipeg, Manitoba, R3A 1R9, Canada
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48208, United States
Hospital Universitari Germans Trias i Pujol
RECRUITING

Badalona, Barcelona, 21A 08916, Spain
Iwate Prefectural Central Hospital
RECRUITING

Morioka, Japan
Japanese Red Cross Kyoto Daini Hospital
RECRUITING

Kyoto, Japan
Jichi Medical University Hospital
RECRUITING

Shimotsuke, Japan
John Radcliffe Hospital
RECRUITING

Oxford, Oxfordshire, OX3 9DU, United Kingdom
KMU University Hospital
RECRUITING

Osaka, Japan
Kagoshima City Hospital
RECRUITING

Kagoshima, Japan
Kaiser Permanente Baldwin Park Medical Center
RECRUITING

Baldwin Park, California, 91706, United States
Kaiser Permanente Downey Medical Center
RECRUITING

Downey, California, 90242, United States
Kaiser Permanente Fontana Medical Center
RECRUITING

Fontana, California, 92335, United States
Kaiser Permanente Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90027, United States
Kaiser Permanente Riverside Medical Center
RECRUITING

Riverside, California, 92505, United States
Kaiser Permanente South Bay Medical Center
RECRUITING

Harbor City, California, 90710, United States
Kaiser Permanente West Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90034, United States
Kobe City Medical Center General Hospital
RECRUITING

Kobe, Japan
Kyorin University Hospital
RECRUITING

Tokyo, Japan
Kyushu Medical Center
RECRUITING

Fukuoka, Japan
M Health Fairview Ridges Hospital,
RECRUITING

Burnsville, Minnesota, 55337, United States
M Health Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
M Health Fairview St. John's Hospital
RECRUITING

Maplewood, Minnesota, 55109, United States
M Health Fairview University of Minnesota Medical Center Hospital,
RECRUITING

Minneapolis, Minnesota, 55455, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Saint Marys Campus
RECRUITING

Rochester, Minnesota, 55902, United States
Medical University of South Carolina University Hospital
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Hermann Memorial City Medical Center
RECRUITING

Houston, Texas, 77024, United States
Memorial Hermann-Texas Medical Center
RECRUITING

Houston, Texas, 77030, United States
Mills Peninsula Medical Center
RECRUITING

Burlingame, California, 94010, United States
Mount Sinai West
RECRUITING

New York, New York, 10019, United States
NHO Osaka National Hospital
RECRUITING

Osaka, Japan
Nakamura Memorial Hospital
RECRUITING

Sapporo, Japan
National Cerebral and Cardiovascular Center
RECRUITING

Suita, Osaka, 564-8565, Japan
Niigata City General Hospital
RECRUITING

Niigata, Japan
North Shore University Hospital
RECRUITING

Manhasset, New York, 11030, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
OSU Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
Ottawa Hospital Research Institute
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Prisma Health Greenville Memorial Hospital
RECRUITING

Greenville, South Carolina, 29605, United States
Providence St. Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States
Queens Medical Centre
RECRUITING

Nottingham, United Kingdom
Riverside Methodist Hospital
RECRUITING

Columbus, Ohio, 43214, United States
Ronald Reagan UCLA Medical Center
RECRUITING

Los Angeles, California, 90095, United States
Royal Stoke University Hospital
RECRUITING

Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom
Royal Victoria Infirmary
RECRUITING

Newcastle upon Tyne, United Kingdom
San Francisco General Hospital
RECRUITING

San Francisco, California, 94110, United States
Santa Creu and Sant Pau Hospital
RECRUITING

Barcelona, Catalonia, 08025, Spain
St. John Medical Center
RECRUITING

Tulsa, Oklahoma, 74104, United States
St. Michaels Hospital
RECRUITING

Toronto, Ontario, M5B 1W8, Canada
Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States
Sunnybrook Health Sciences Center
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Temple University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
The Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
The Queen's Medical Center
RECRUITING

Honolulu, Hawaii, 96813, United States
Toranomon Hospital
RECRUITING

Tokyo, Japan
UC Davis Medical Center
RECRUITING

Sacramento, California, 95817, United States
UC Irvine Medical Center,
RECRUITING

Orange, California, 92868, United States
UCSD Health La Jolla
RECRUITING

La Jolla, California, 92037, United States
UCSD Medical Center - Hillcrest Hospital
RECRUITING

San Diego, California, 92103, United States
UF Health Shands Hospital
RECRUITING

Gainesville, Florida, 32608, United States
UMass Memorial Medical Center
RECRUITING

Worcester, Massachusetts, 01605, United States
University Hospital Augsburg
RECRUITING

Augsburg, 86156, Germany
University Hospital Erlangen
RECRUITING

Erlangen, Bavaria, 91054, Germany
University Hospital Heidelberg
RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany
University Hospital Tuebingen
RECRUITING

Tübingen, 72076, Germany
University Medical Center Hamburg
RECRUITING

Hamburg, 20246, Germany
University of Alabama Hospital
RECRUITING

Birmingham, Alabama, 35233, United States
University of Alberta Hospital
RECRUITING

Edmonton, Alberta, AB T6G 2B7, Canada
University of Calgary - Foothills Medical Centre
RECRUITING

Calgary, Alberta, Canada
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
University of Montreal Hospital
RECRUITING

Montreal, Quebec, H2X 3E4, Canada
University of Utah Healthcare
RECRUITING

Salt Lake City, Utah, 84132, United States
VCU Medical Center
RECRUITING

Richmond, Virginia, 23219, United States
Vall d'Hebron University Hospital (VHUH)
RECRUITING

Horta, Barcelona, Spain
Valladolid University Hospital
RECRUITING

Valladolid, 47002, Spain
Vancouver General Hospital
RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
WellStar Kennestone Hospital
RECRUITING

Marietta, Georgia, 30060, United States

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