New Total-Body PET scanner could revolutionize vasculitis diagnosis

NCT ID NCT07628075

Not yet recruiting Diagnosis Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potentially allowing for lower radiation doses and better detection of disease activity. Researchers will compare scans from 18 participants (12 with LVV and 6 healthy volunteers) to develop a standardized imaging protocol for future use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 18F-FDG (a radioactive sugar) and CT contrast dye
What this could lead to: If successful, this could lead to a standardized, more accurate imaging protocol for diagnosing and monitoring large vessel vasculitis, potentially reducing unnecessary treatments.
What could go wrong: This is a very small, early-phase study (18 participants) focused on optimizing the imaging technique, not testing a treatment. The new method may not prove clearly better than current scans.

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Conditions

The condition(s) this trial relates to.

Giant Cell Arteritis Takayasu arteritis temporal arteritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GIANT CELL ARTERITIS (GCA) LARGE VESSEL VASCULITIS TAKAYASU ARTERITIS

Contacts and locations

Locations

Imperial College Healthcare NHS Trust

London, Greater London, W2 1NY, United Kingdom
King's College London

London, Greater London, SE1 7EH, United Kingdom
Royal Free London NHS Foundation Trust

London, Greater London, NW3 2QG, United Kingdom

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