Could two old drugs beat one for migraine prevention?

NCT ID NCT07655700

Not yet recruiting Disease control Sponsor: Chittagong Medical College Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether taking two inexpensive migraine prevention drugs together works better than taking either one alone. Adults aged 18 to 55 who have at least four migraines per month will receive propranolol, flunarizine, or both for 12 weeks. The goal is to see which approach reduces monthly migraine days most effectively and safely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: propranolol and flunarizine (alone or combined)
What this could lead to: If the combination works better, it could offer a more effective, affordable option for preventing frequent migraines without needing expensive new drugs.
What could go wrong: This is a single-center, open-label trial, so results may not apply broadly. Side effects from either drug or the combination could limit use, and the 12-week duration may not reflect long-term benefits.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE PROPHYLAXIS

Contacts and locations

Locations

Chittagong Medical College

Chittagong, 4203, Bangladesh

More trials for these conditions

Other studies related to the condition(s) this trial covers.