Can fewer eye injections work just as well? new trial tests flexible dosing for diabetic macular edema
NCT ID NCT05610319
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways of giving faricimab, a drug injected into the eye, to treat diabetic macular edema (DME). One group gets injections on a fixed monthly schedule, while the other uses a 'treat and extend' approach where the time between injections is gradually lengthened if the eye remains stable. The goal is to see if the flexible schedule can maintain vision with fewer clinic visits. About 446 adults with DME are taking part across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Faricimab (injected into the eye)
What this could lead to
If successful, this could show that a flexible dosing schedule works as well as fixed monthly injections, potentially reducing the number of eye injections patients need.
What could go wrong
This is a Phase 4 trial comparing two already-approved dosing strategies, so it is not testing a new drug. The flexible schedule may not be as effective for all patients, and eye injections carry risks like infection or inflammation.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Adelaide Eye & Retina Centre
Adelaide, South Australia, 5000, Australia
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Alberta Retina Consultants
Calgary, Alberta, T5H 0X5, Canada
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Austin Retina Associates
Austin, Texas, 78705, United States
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Bradford Royal Infirmary
Bradford, England, United Kingdom
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Calgary Retina Consultants
Calgary, Alberta, T2H 0C8, Canada
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Centre for Eye Research Australia
East Melbourne, Victoria, 3002, Australia
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Eastern Suburbs Eye Specialists
Bondi Junction, New South Wales, 2022, Australia
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Eye Associates of Northeast Louisiana Dba Haik Humble Eye Center
West Monroe, Louisiana, 71291, United States
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Eye Clinic Albury Wodonga
Albury, New South Wales, 2640, Australia
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Frimley Health
Frimley, England, United Kingdom
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Hobart Eye Surgeons
Hobart, Tasmania, 7008, Australia
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King's College Hospital
London, England, United Kingdom
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Lane Cove Eye
Lane Cove, New South Wales, 2066, Australia
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Lions Eye Institute Limited
Nedlands, Western Australia, 6009, Australia
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Liverpool University Hospitals
Liverpool, England, United Kingdom
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London North West University
London, England, United Kingdom
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Maisonneuve-Rosemont Hospital
Montreal, Quebec, H1T 2M4, Canada
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Marsden Eye Specialists
Parramatta, New South Wales, 2150, Australia
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Mississippi Retina Associates
Jackson, Mississippi, 39202, United States
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Moorfields Eye Hospital
London, England, United Kingdom
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Nexus Eyecare Blacktown
Blacktown, New South Wales, Australia
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Queensland Eye Institute
Woolloongabba, Queensland, 4012, Australia
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Retina & Vitreous of Texas
Bellaire, Texas, 77401, United States
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Retina Consultants of Houston, dba Retina Consultants of Texas
Bellaire, Texas, 77401, United States
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Retina Consultants of Houston, dba Retina Consultants of Texas
San Antonio, Texas, 78240, United States
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Retina Consultants of Texas
Beaumont, Texas, 77707, United States
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Retina Institute of Ottawa
Ottawa, Ontario, K2B 7E9, Canada
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Retina Specialists Victoria
Rowville, Victoria, 3178, Australia
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Retina Surgical Associates
New Westminster, British Columbia, V3L 5H1, Canada
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Retina and Eye Consultants
Hurstville, New South Wales, 2220, Australia
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Retinal Consultants Medical Group Inc.
Modesto, California, 95356, United States
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South Eastern Sydney Health
Sydney, New South Wales, 2000, Australia
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South West Retina
Liverpool, New South Wales, 2170, Australia
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St. Joseph's Healthcare London
London, Ontario, N6A 4V2, Canada
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Strathfield Retina Clinic
Strathfield, New South Wales, 2135, Australia
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Sydney Retina
Sydney, New South Wales, 2000, Australia
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The Research Institute of St. Joe's Hamilton
Hamilton, Ontario, L8G 5E4, Canada
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The Royal Wolverhampton
Wolverhampton, England, United Kingdom
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Toronto Retina Institute
Toronto, Ontario, M3C 0G9, Canada
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UBC Eye Centre, Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9, Canada
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University Hospitals Bristol-Weston
Bristol, England, United Kingdom
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University Retina and Macula Associates
Oak Forest, Illinois, 60452, United States
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Valley Retina Institute
McAllen, Texas, 78503, United States
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Vitreo-Retina Medical Group
Sacramento, California, 95825, United States
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Vitreous Retina Macula Specialists of Toronto
Toronto, Ontario, M8X 2X3, Canada
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West Coast Retina
Vancouver, British Columbia, V5Z 1K1, Canada