New pill could fight diabetic eye swelling
NCT ID NCT05727891
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tests whether the oral drug tonabersat can reduce retinal swelling in people with diabetic macular edema who still have good vision. About 128 adults with type 1 or 2 diabetes will take either tonabersat or a placebo daily for several months. The main goal is to see if the drug decreases the thickness of the central retina, a key sign of fluid buildup.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tonabersat (80 mg pill taken once daily)
What this could lead to
If it works, tonabersat could offer a new oral treatment option to reduce retinal swelling in people with diabetic macular edema who still have good vision.
What could go wrong
This is an early Phase 2 trial with only 128 participants, so results may not apply to everyone. The primary outcome is a measure of retinal thickness, not vision improvement, and the drug may not show meaningful benefit over placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Boston Medical Center Corporation
Boston, Massachusetts, 02118, United States
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Central Florida Retina Institute
Lakeland, Florida, 33805, United States
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East Bay Retina Consultants, Inc.
Oakland, California, 94609, United States
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Elman Retina Group
Baltimore, Maryland, 21237, United States
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Florida Retina Consultants
Lakeland, Florida, 33805, United States
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Hilton Head Retina Institute
Hilton Head Island, South Carolina, 29926, United States
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Illinois Retina Associates
Oak Park, Illinois, 60304, United States
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Joseph E. Humble and Raymond Haik PTRS DBA Eye Assoc of Northeast Louisiana
West Monroe, Louisiana, 71291, United States
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Joslin Diabetes Center
Boston, Massachusetts, 02215, United States
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Loma Linda University
Loma Linda, California, 92354, United States
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Macula Retina Vitreous Institute
Torrance, California, 90503, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Midwest Eye Institute
Indianapolis, Indiana, 46290, United States
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National Ophthalmic Research Institute
Fort Myers, Florida, 33912, United States
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Pittsburg Clinical Trial Consortium
Sewickley, Pennsylvania, 15143, United States
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Retina Associates of Southern California
Huntington Beach, California, 92647, United States
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Retina Consultants of Texas, PA
Bellaire, Texas, 77401, United States
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Retina Research Institute, LLC
St Louis, Missouri, 63128, United States
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Retina-Vitreous Surgeons of Central NY, PC
Liverpool, New York, 13088, United States
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Retinal Consultants of Texas
San Antonio, Texas, 78240, United States
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Southeast Eye Institute, P.A. dba Eye Associates of Pinellas
Pinellas Park, Florida, 33782, United States
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Southeast Retina Center
Augusta, Georgia, 30909, United States
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Southern California Desert Retina Consultants, Inc.
Palm Desert, California, 92211, United States
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Texas Retina Associates
Lubbock, Texas, 79424, United States
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The Trustees of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Thomas Eye Group
Sandy Springs, Georgia, 30328, United States
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University of Florida- Jacksonville
Jacksonville, Florida, 32209, United States
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Verum Research LLC
Eugene, Oregon, 97401, United States