Gene therapy injection aims to restore sight in rare eye diseases
NCT ID NCT06460844
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a single injection of a gene therapy called RTx-015 in 10 adults with retinitis pigmentosa or choroideremia, two inherited conditions that cause vision loss. The therapy delivers a gene that makes retinal cells produce a light-sensitive protein, potentially helping them respond to light. The main goal is to check safety, not yet to prove it improves vision.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- RTx-015 (gene therapy injection into the eye)
- What this could lead to
- If it works, this could point toward a treatment that helps people with certain inherited eye diseases see better by making light-sensitive proteins in the retina.
- What could go wrong
- This is a very early, small safety study with only 10 people. It is not designed to prove the treatment works, and there may be side effects from the injection or the gene therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Retina Consultants of Texas Research Centers
Bellaire, Texas, 77401, United States
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Retina Vitreous Associates Medical Group
Beverly Hills, California, 90211, United States
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UCI Alpha Clinic
Orange, California, 92868, United States
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UPMC Vision Institute
Pittsburgh, Pennsylvania, 15221, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A sharper look at the retina: new imaging technology may spot eye disease earlier
- Stem cell eye transplant aims to halt blindness from rare genetic disease
- Gene Therapy's lasting effects on vision tracked in Long-Term study
- Could stem cells restore sight in damaged eyes?
- Gene therapy injection aims to restore sight in rare blindness
- Ground-Level vision test could help retinitis pigmentosa patients walk better