RETINITIS PIGMENTOSA

This early-stage study tests a new drug called ZM-02 for people with retinitis pigmentosa, a genetic eye disease that causes vision loss. The main goal is to check safety, not to cure the disease. Twelve participants will receive one injection into one eye, and researchers will m…

This study tests a one-time injection of retinal sheets made from stem cells into the eye of 12 adults with retinitis pigmentosa, a genetic condition that causes progressive vision loss. The main goal is to see if the treatment is safe and tolerable. Participants are grouped by t…

This early-stage trial tests a gene therapy called BS01 for people with retinitis pigmentosa, a condition that causes gradual vision loss. The treatment uses a harmless virus to deliver a light-sensitive protein to cells in the eye, aiming to help them detect light again. About 2…

This study tests a new drug called KIO-301, given as an eye injection, for people with late-stage retinitis pigmentosa, a genetic eye disease that causes severe vision loss. The goal is to see if the drug is safe and can improve vision in patients who have little or no light perc…

This study tests a new drug called OCT-980 in people with a genetic form of retinitis pigmentosa, an eye disease that leads to vision loss. The trial first checks safety in healthy volunteers, then tests the drug in patients to see if it can slow or stop the disease. About 50 par…

This study tests a new retinal implant (AuTNA I) in 7 adults with retinitis pigmentosa, a genetic eye disease that causes vision loss. The implant is placed under the retina and aims to safely improve light sensitivity and vision. Researchers will check safety and measure any vis…

This study tests a one-time gene therapy injection into the eye for people with advanced retinitis pigmentosa caused by mutations in the RHO, PDE6A, or PDE6B genes. The goal is to see if it is safe and can slow vision loss. About 33 adults will take part, and the study will follo…

This study tests the safety of a single injection of jCell, made from retinal cells, in 60 adults with retinitis pigmentosa, a genetic eye disease that causes vision loss. Participants are randomly assigned to get the real injection or a sham procedure. The main goal is to check …

This early study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve eyesight in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study invo…

This study follows 45 adults with retinitis pigmentosa caused by EYS gene mutations to understand how their vision changes over four years. Researchers will measure things like visual field and retinal function to find the best tests for future treatment trials. Participants must…

This study aims to learn how well people with retinal diseases (like retinitis pigmentosa and Stargardt's disease) see in the dark compared to healthy volunteers. Researchers will use special vision tests and eye exams to see if dark adaptation can help detect and track these dis…

This study is for people with retinal diseases like retinitis pigmentosa or Stargardt disease who have low vision. Researchers want to see if certain vision tests can be done reliably by these patients. The goal is to develop better ways to measure vision in future clinical trial…

This study uses a special camera called adaptive optics to take detailed pictures of the back of the eye in people with outer retinal diseases, such as age-related macular degeneration and retinitis pigmentosa. The goal is to develop new ways to diagnose and track these diseases.…

This study collects skin, hair, blood, urine, or saliva samples from people with certain eye diseases (like macular degeneration) and from healthy volunteers. Researchers will turn these cells into stem cells in the lab to study how the diseases develop and to test potential new …

This study uses a special camera to take extremely detailed pictures of the retina (the back of the eye) in both healthy people and those with eye diseases like Stargardt's or age-related macular degeneration. The goal is to see individual cells and blood vessels to better unders…

This study is for people with rare inherited retinal diseases like retinitis pigmentosa. It has two parts: a registry that collects genetic and vision information, and a natural history study that follows vision changes over time. No new treatments are tested—the goal is to bette…

This study uses high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand diseases like glaucoma, macular degeneration, and diabetes-related eye problems.…