RETINITIS PIGMENTOSA

This study is testing a gene therapy called AAV5-hRKp.RPGR to see if it is safe and can help preserve or improve vision in Japanese patients with a specific, inherited form of retinitis pigmentosa (XLRP). The therapy involves a one-time injection into the back of both eyes to del…

This early-stage study is testing the safety of a single gene therapy injection, called SPVN06, for adults with an advanced form of retinitis pigmentosa caused by specific genetic mutations. The goal is to see if delivering a working gene directly to the retina can slow or stop t…

This study is testing whether repeated injections of an experimental drug called KIO-301 into the eye is safe and can help improve vision in people with late-stage retinitis pigmentosa, a genetic disease that causes severe vision loss. It will involve about 36 adults who have ver…

This is the first study in people to test the safety and early effects of an experimental gene therapy called ZM-02 for retinitis pigmentosa (RP), an inherited disease that causes progressive vision loss. About 12 adults with RP will receive either a single injection of the thera…

This early-stage study is testing the safety and tolerability of an experimental drug called KIO-301, which is injected directly into the eye. It aims to help adults aged 18-80 with severe vision loss from genetic eye diseases like retinitis pigmentosa and choroideremia. The main…

This trial is testing a new gene therapy called BS01 for people with retinitis pigmentosa, a genetic eye disease that causes vision loss. The therapy uses a harmless virus to deliver a special light-sensitive protein directly into the eye, aiming to help remaining cells detect li…

This early-stage study is testing the safety of a new treatment for retinitis pigmentosa, a genetic eye disease that causes vision loss. Researchers will implant lab-grown retinal tissue into the eyes of 12 adult participants to see if it's safe and if it might help preserve or i…

This study is testing the safety of a single injection of an experimental cell therapy called jCell into the eye of adults with retinitis pigmentosa (RP), a genetic eye disease that causes vision loss. Over 60 participants will be randomly assigned to receive either the real inje…

This is the first study in people for an oral medication called OCT-980, designed to treat a specific genetic form of retinitis pigmentosa, an inherited disease that causes progressive vision loss. The study will first test single doses in healthy volunteers to check safety, then…

This is a small, early-stage study to test the safety and effectiveness of a new retinal implant called AuTNA I. The device is surgically placed under the retina in one eye of people with advanced retinitis pigmentosa, a genetic eye disease that causes blindness. Researchers will…

This study is testing whether disulfiram, a medication used to treat alcohol use disorder, can improve vision in people with retinal degeneration diseases like macular degeneration and retinitis pigmentosa. The trial will enroll 15 adults who have both a retinal condition and alc…

This study aims to understand how vision declines over time in adults with a specific genetic form of retinitis pigmentosa (RP) caused by mutations in the EYS gene. Researchers will follow 45 participants for four years, using detailed eye exams to measure changes in their vision…

This study aims to understand and eventually find treatments for serious eye diseases that can lead to blindness, like macular degeneration. Researchers will collect simple samples like hair, skin, or blood from people with these conditions and from healthy volunteers. In the lab…

This study aims to test new, high-tech eye imaging systems that can see microscopic details of the eye, like individual cells and blood flow, which are not visible with standard equipment. Researchers will enroll 1,200 participants, including people with various eye conditions an…

This study aims to understand how retinal diseases affect vision, especially in low light. Researchers will measure how well 500 participants, including healthy people and those with conditions like retinitis pigmentosa, can see in the dark. The goal is to see if these dark-adapt…

This study aims to build a detailed registry and track the natural progression of rare genetic eye diseases that cause vision loss, like retinitis pigmentosa. It will follow 1,500 participants worldwide who have specific rare genetic variants to understand how their vision change…