Blood's tiny RNA clues could unlock the stroke 'Clock'

NCT ID NCT03905434

First seen Aug 17, 2026 ยท Last updated Aug 17, 2026

Summary

This study looks at whether tiny RNA particles called exosomal microRNAs in the blood can act as a 'stroke clock' for people with a severe type of stroke caused by a blocked large artery in the front of the brain. Researchers will compare blood samples from stroke patients to healthy controls to see if certain microRNAs are different. They will also check if these microRNAs differ between patients with good versus poor collateral blood flow, which might help doctors estimate stroke onset time and guide treatment.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Blood sampling for exosomal microRNA analysis
What this could lead to
If certain microRNAs are found, they could become a blood test to estimate stroke onset time and guide treatment decisions.
What could go wrong
This is a small, early study. The identified microRNAs may not be specific or reliable enough for clinical use, and results may not generalize beyond this patient group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23298, United States

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