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Could melatonin help save Babies' brains after birth injury?

NCT ID NCT07305350

Ongoing Disease control Sponsor: University of Child Health Sciences and Children's Hospital, Lahore Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving melatonin to full-term newborns with hypoxic-ischemic encephalopathy (HIE) — a type of brain injury from lack of oxygen at birth — can improve survival and reduce brain damage. Half of the 110 babies will receive a single dose of melatonin through a feeding tube plus standard care, while the other half gets standard care alone. Researchers will check survival at 28 days and brain injury scores at days 1, 3, and 7.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Melatonin
What this could lead to
If it works, this could point toward a simple, safe treatment to improve survival and reduce brain damage in newborns with HIE.
What could go wrong
This is a small, early-phase trial with only 110 babies, so results may not be definitive. Melatonin's benefit is unproven, and standard care already includes intensive monitoring.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia perinatal asphyxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOXIC ISCHAEMIC ENCEPHALOPATHY (HIE)

Contacts and locations

Locations

  • Children Hospital and University of Child Health Sciences, Lahore

    Lahore, Punjab Province, 05411, Pakistan

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