New pill could stop Period-Linked migraines before they start

NCT ID NCT06417775

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 4 times

Summary

This study tests whether the drug ubrogepant can prevent menstrual migraines when taken daily for a week around each period. About 496 women with regular cycles and a history of menstrual migraines will receive either ubrogepant or a placebo for three cycles, then all may receive the drug for a year. The goal is to see if it safely reduces the number of migraine days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ubrogepant (UBRELVY)
What this could lead to: If successful, this could offer a new short-term preventive option for women with menstrual migraines, reducing the number of migraine days each cycle.
What could go wrong: This is a phase 3 trial, but it's still testing an investigational use. The drug may not work better than placebo, and side effects are possible. Results may not apply to all migraine types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

Locations

Abington Neurological Associates - Abington /ID# 257164

Abington, Pennsylvania, 19001, United States
Accel Research Sites - Lakeland Clinical Research Unit /ID# 257874

Lakeland, Florida, 33803, United States
Accel Research Sites Network - DeLand Clinical Research Unit /ID# 257403

DeLand, Florida, 32720, United States
Accellacare - McFarland Clinic /ID# 257834

Ames, Iowa, 50010, United States
Accellacare - South Hawthorne Road - Winston-Salem /ID# 257731

Winston-Salem, North Carolina, 27103, United States
Accellacare - South Hawthorne Road - Winston-Salem /ID# 257850

Winston-Salem, North Carolina, 27103, United States
Advanced Research Institute /ID# 257853

Ogden, Utah, 84405, United States
Albuquerque Clinical Trials, Inc. /ID# 257212

Albuquerque, New Mexico, 87102, United States
Alliance For Multispeciality Research - Wichita East /ID# 257148

Wichita, Kansas, 67207, United States
Alliance for Multispecialty Research - Clinical Research Associates /ID# 257851

Norfolk, Virginia, 23502, United States
Alliance for Multispecialty Research - Knoxville /ID# 257846

Knoxville, Tennessee, 37920, United States
Alliance for Multispecialty Research LLC /ID# 257839

Newton, Kansas, 67114, United States
Artemis Institute for Clinical Research - San Diego /ID# 257134

San Diego, California, 92103-2204, United States
Axiom Research - Irvine /ID# 264083

Irvine, California, 92604, United States
Axiom Research /ID# 257833

Colton, California, 92324, United States
Axiom Research, LLC-Los Angeles /ID# 264085

Glendale, California, 91206, United States
BDH Research /ID# 262851

San Juan, 00927, Puerto Rico
BNL Health - Los Angeles Headache Center /ID# 257237

Los Angeles, California, 90067-2001, United States
BTC of New Bedford /ID# 257128

New Bedford, Massachusetts, 02740, United States
Bio Behavioral Health, Inc /ID# 257140

Toms River, New Jersey, 08755-6434, United States
Boston Clinical Trials /ID# 257132

Boston, Massachusetts, 02131-2515, United States
C7 Research /ID# 272815

Cleveland, Ohio, 44109, United States
CTI Clinical Research Center /ID# 257162

Cincinnati, Ohio, 45212-3784, United States
CenExel Collaborative Neuroscience Research /ID# 257828

Los Alamitos, California, 90720, United States
Central Research Associates /ID# 260161

Birmingham, Alabama, 35205, United States
Central States Research /ID# 277867

Tulsa, Oklahoma, 74136, United States
Centricity Research Columbus /ID# 257221

Columbus, Ohio, 43213, United States
Charlottesville Medical Research /ID# 257154

Charlottesville, Virginia, 22911, United States
Clinical Neuroscience Solutions, Inc /ID# 257190

Orlando, Florida, 32801-2986, United States
Clinical Research Atlanta - Headlands LLC /ID# 260181

Stockbridge, Georgia, 30281-9054, United States
Clinical Research of Philadelphia, LLC /ID# 257197

Philadelphia, Pennsylvania, 19114, United States
Clinpoint Trials /ID# 274524

Waxahachie, Texas, 75165, United States
Clinvest Research LLC /ID# 257215

Springfield, Missouri, 65807, United States
Coastal Carolina Research Center - North Charleston /ID# 257227

North Charleston, South Carolina, 29405, United States
Cognitive Clinical Trials (CCT) - Papillion /ID# 260174

Papillion, Nebraska, 68046-4131, United States
Collective Medical Research /ID# 257131

Overland Park, Kansas, 66210, United States
Conquest Research /ID# 258314

Winter Park, Florida, 32789, United States
Deaconess Midtown Hospital /ID# 257400

Evansville, Indiana, 47710, United States
Dent Neurologic Institute - Amherst /ID# 257219

Amherst, New York, 14226, United States
Elevate Clinical - Seabrook /ID# 274679

Houston, Texas, 77058, United States
Epic Clinical Research - Lewisville /ID# 274480

Lewisville, Texas, 75057, United States
Fieve Clinical Research, Inc. /ID# 257177

New York, New York, 10017-1921, United States
Foothill Family Draper Clinic /ID# 277876

Draper, Utah, 84020, United States
Foothills Research Center/CCT Research /ID# 260180

Phoenix, Arizona, 85044, United States
FutureSearch Trials of Dallas, LP /ID# 257142

Dallas, Texas, 75231, United States
FutureSearch Trials of Neurology /ID# 257186

Austin, Texas, 78731, United States
Gilbert Neurology /ID# 260179

Gilbert, Arizona, 85297, United States
Hawaii Pacific Neuroscience /ID# 274469

Honolulu, Hawaii, 96817, United States
Headache Wellness Center /ID# 257136

Greensboro, North Carolina, 27405, United States
Headlands PharmaSite /ID# 257208

Baltimore, Maryland, 21208, United States
HealthCare Research Network - Hazelwood /ID# 257402

Hazelwood, Missouri, 63042, United States
Healthcare Research Network /ID# 257868

Tinley Park, Illinois, 60477, United States
Highland Clinical Research /ID# 257137

Salt Lake City, Utah, 84124, United States
Hope Clinical Research /ID# 257867

Canoga Park, California, 91303, United States
Houston Clinical Research Associates /ID# 272077

Houston, Texas, 77090, United States
IMA Clinical Research Las Vegas /ID# 258679

Las Vegas, Nevada, 89102-1955, United States
IMA Clinical Research Monroe - Wood /ID# 259362

Monroe, Louisiana, 71201, United States
IMA Clinical Research Warren /ID# 263641

Warren Township, New Jersey, 07059, United States
IMA Clinical Research Westchester /ID# 259157

Hartsdale, New York, 10530, United States
ISIS Clinical Research Center /ID# 262858

Guaynabo, 00969-2806, Puerto Rico
Indago Research and Health Center /ID# 277943

Miami Lakes, Florida, 33016, United States
Instituto De Neurologia Dra. Ivonne Fraga /ID# 262852

San Juan, 00918, Puerto Rico
J. Lewis Research - Salt Lake City - Foothill Drive /ID# 277877

Salt Lake City, Utah, 84109, United States
J. Lewis Research, Inc. / Foothill Family Clinic South /ID# 258305

Salt Lake City, Utah, 84121-6923, United States
KCA Neurology /ID# 274495

Franklin, Tennessee, 37067, United States
Lillestol Research, LLC /ID# 257896

Fargo, North Dakota, 58104, United States
Lynn Institute of Oklahoma City /ID# 257857

Oklahoma City, Oklahoma, 73112, United States
M3 Wake Research - Convoy /ID# 257897

San Diego, California, 92111, United States
M3 Wake Research - Newport Beach /ID# 257158

Newport Beach, California, 92660, United States
M3 Wake Research-Las Vegas Rainbow /ID# 257895

Las Vegas, Nevada, 89118-2557, United States
MD First Research - Chandler /ID# 262564

Chandler, Arizona, 85286, United States
MedVadis Research /ID# 257156

Waltham, Massachusetts, 02451, United States
Memorial Healthcare Institute For Neuroscience /ID# 274663

Owosso, Michigan, 48867, United States
Methodist Physicians Clinic/CCT Research /ID# 260167

Fremont, Nebraska, 68025, United States
Michigan Headache & Neurological Institute (MHNI) /ID# 257179

Ann Arbor, Michigan, 48104-5131, United States
Mind+ Neurology /ID# 274486

Mequon, Wisconsin, 53092, United States
Neuro Pain Research Center /ID# 257155

Fresno, California, 93710, United States
NeuroTrials Research /ID# 274507

Atlanta, Georgia, 30328, United States
Neurology Offices of South Florida, PLLC /ID# 257161

Boca Raton, Florida, 33428-2231, United States
New England Institute for Clinical Research /ID# 264019

Stamford, Connecticut, 06905, United States
Northwest Clinical Research Center /ID# 257381

Bellevue, Washington, 98007, United States
Optimus Medical /ID# 257856

San Francisco, California, 94102, United States
Partners In Clinical Research /ID# 257855

Cumberland, Rhode Island, 02864, United States
Preferred Research Partners /ID# 262786

Little Rock, Arkansas, 72211, United States
Preferred Research Partners /ID# 273128

Little Rock, Arkansas, 72211, United States
Premier Neurology /ID# 260359

Greenville, South Carolina, 29605, United States
Proven Endpoints LLC /ID# 273796

Ridgeland, Mississippi, 39157, United States
Puget Sound Neurology /ID# 257174

Tacoma, Washington, 25328, United States
Radiance Clinical Research /ID# 271727

Lampasas, Texas, 76550, United States
Red Star Research, LLC /ID# 257871

Lake Jackson, Texas, 77566, United States
Rehabilitation and Neurological Services /ID# 275593

Huntsville, Alabama, 35805, United States
Rochester Clinical Research /ID# 257193

New York, New York, 14609, United States
Sensible Healthcare /ID# 257198

Ocoee, Florida, 34761, United States
Sms Clinical Research /ID# 278443

Mesquite, Texas, 75149, United States
Summit Research Network - Portland - Northwest Vaughn Street /ID# 257139

Portland, Oregon, 97210, United States
Sun Valley Research Center /ID# 257152

Imperial, California, 92251-9401, United States
Tandem Clinical Research - Marrero - Barataria Boulevard /ID# 260146

Marrero, Louisiana, 70072, United States
Trialmed-Synexus Clinical Research US, Inc. - Tucson /ID# 258309

Tucson, Arizona, 85741, United States
True North Neurology /ID# 274672

Port Jefferson Station, New York, 11776, United States
Upstate Clinical Research Associates /ID# 257163

Williamsville, New York, 14221-6046, United States
Vaught Neurological Services /ID# 267519

Beckley, West Virginia, 25801, United States
Velocity Clinical Research - Boise /ID# 257135

Meridian, Idaho, 83642, United States
WR-ClinSearch /ID# 257160

Chattanooga, Tennessee, 37421-1605, United States
Well Pharma Medical Research /ID# 257199

Miami, Florida, 33143, United States
West Virginia Univ School Med /ID# 258898

Morgantown, West Virginia, 26506, United States
Wright State Physicians Health Center /ID# 274708

Fairborn, Ohio, 45324, United States

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