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Can a drug prevent gut problems and pneumonia in Brain-Injured patients?

NCT ID NCT05008926

Terminated Disease control Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial aims to see if giving naloxegol early can reduce these risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Naloxegol
What this could lead to
If it works, this could point toward a way to prevent constipation and pneumonia in brain-injured patients on opioids in the ICU.
What could go wrong
The trial is currently suspended, so results are uncertain. It is also a prevention study in a specific ICU population, so benefits may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic brain injury subarachnoid hemorrhage traumatic brain injury opioid-induced constipation prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN INJURIES

Contacts and locations

Locations

  • CHU Bordeaux

    Bordeaux, 33000, France

  • CHU Brest

    Brest, 29609, France

  • CHU Nantes

    Nantes, 44093, France

  • CHU Tours - Hôpital BRETONNEAU

    Tours, 37000, France

  • CHU Tours - Hôpital TROUSSEAU

    Tours, 37170, France

  • CHU de Bordeaux - Réanimation chirurgicale

    Bordeaux, France, 33000, France

  • CHU de Lille

    Lille, 59000, France

  • CHU de Montpellier

    Montpellier, 34295, France

  • CHU de Strasbourg

    Strasbourg, 67098, France

  • Hôpital La Pitié Salpétrière (APHP)

    Paris, 75013, France

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