Can a drug prevent gut problems and pneumonia in Brain-Injured patients?
NCT ID NCT05008926
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial aims to see if giving naloxegol early can reduce these risks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Naloxegol
What this could lead to
If it works, this could point toward a way to prevent constipation and pneumonia in brain-injured patients on opioids in the ICU.
What could go wrong
The trial is currently suspended, so results are uncertain. It is also a prevention study in a specific ICU population, so benefits may not apply broadly.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Bordeaux
Bordeaux, 33000, France
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CHU Brest
Brest, 29609, France
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CHU Nantes
Nantes, 44093, France
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CHU Tours - Hôpital BRETONNEAU
Tours, 37000, France
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CHU Tours - Hôpital TROUSSEAU
Tours, 37170, France
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CHU de Bordeaux - Réanimation chirurgicale
Bordeaux, France, 33000, France
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CHU de Lille
Lille, 59000, France
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CHU de Montpellier
Montpellier, 34295, France
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CHU de Strasbourg
Strasbourg, 67098, France
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Hôpital La Pitié Salpétrière (APHP)
Paris, 75013, France