New injection schedule may boost vision in diabetic eye disease

NCT ID NCT04116398

Ongoing Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tests a new treatment plan for diabetic macular edema, a condition that causes vision loss. Instead of waiting for severe swelling, patients receive two dexamethasone implants 12 weeks apart, then additional injections only as needed. The goal is to improve vision while keeping the number of injections low. The trial includes 53 adults with significant macular thickening.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexamethasone implant (Ozurdex)
What this could lead to: If successful, this could offer a more effective treatment schedule for diabetic macular edema, potentially improving vision while reducing the number of injections needed.
What could go wrong: This is a small, early-phase study with only 53 participants, so results may not apply to everyone. The treatment involves eye injections, which carry risks like infection or increased eye pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA

Contacts and locations

Locations

APHM - Hôpital Nord

Marseille, 13015, France
APHP - Hôpital Avicenne

Bobigny, 93000, France
APHP - Hôpital Lariboisière

Paris, 75010, France
CHRU Lille - Hôpital Huriez

Lille, 59037, France
CHU Bordeaux - Hôpital Pellegrin

Bordeaux, 33000, France
CHU Dijon

Dijon, 21079, France
CHU Toulouse - Hôpital Pierre Paul Riquet

Toulouse, 31059, France
CHU de Poitiers - La miletrie

Poitiers, 86000, France
Centre Hospitalier National d'Ophtalmologie des XV XX

Paris, 75012, France
Centre Monticelli Paradis d'ophtalmologie

Marseille, 13008, France
Centre Rétine Gallien

Bordeaux, France
Clinique Juge

Marseille, France
Clinique Mathilde

Rouen, France
Hospices Civils de Lyon - Hopital de la Croix Rousse

Lyon, 69004, France
Hôpital Edouard Herriot

Lyon, 69003, France
Hôpital Intercommunal de Créteil

Créteil, 94010, France

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