Diabetes drug could help Babies' brains heal after birth injury
NCT ID NCT06429007
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests whether metformin, a common diabetes drug, is safe and feasible for infants who suffered brain injury from lack of oxygen at birth. Thirty infants under 6 months old will receive metformin for 6 weeks, with close monitoring of kidney and liver function. The goal is to see if metformin can promote brain repair and improve neurodevelopment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin
What this could lead to
If it works, this could point toward a treatment that helps infants recover brain function after birth injury, improving their development.
What could go wrong
This is a very early Phase 1 trial with only 30 infants, focused on safety and feasibility. It may not show any benefit, and metformin's effects in infants are unknown.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States