Device vs. pills: can a heart plug beat blood thinners for stroke?

NCT ID NCT04226547

First seen Feb 14, 2026 · Last updated May 14, 2026 · Updated 10 times

Summary

This study compares two ways to prevent strokes in people with atrial fibrillation (an irregular heartbeat). One group gets a device called the Amulet that plugs a small pouch in the heart where clots can form. The other group takes standard blood-thinning medication (NOACs). The goal is to see which approach is safer and more effective at preventing strokes, blood clots, and major bleeding. About 2,650 participants are being followed for several years.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AdventHealth Florida Cardiology - Altamonte Springs

    Altamonte Springs, Florida, 32701, United States

  • AdventHealth Florida Cardiology - Lake Mary

    Lake Mary, Florida, 32746, United States

  • AdventHealth Florida Cardiology - Oviedo

    Oviedo, Florida, 32765, United States

  • AdventHealth Orlando

    Orlando, Florida, 32803, United States

  • Arizona Cardiovascular Research Center

    Phoenix, Arizona, 85016, United States

  • Arrhythmia Research Group

    Jonesboro, Arkansas, 72401, United States

  • Baptist Health Lexington

    Lexington, Kentucky, 40503, United States

  • Baptist Medical Center

    Jacksonville, Florida, 32207, United States

  • Baylor All Saints Medical Center at Fort Worth

    Forth Worth, Texas, 76104, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Bryan Heart

    Lincoln, Nebraska, 68506, United States

  • Buffalo General Hospital

    Buffalo, New York, 14203, United States

  • CHI Health Creighton University Medical Center-Bergan Mercy

    Omaha, Nebraska, 68124, United States

  • CHI St. Luke's Health Baylor College of Medicine Med. Ctr.

    Houston, Texas, 77030, United States

  • CHU Gabriel Montpied

    Clermont-Ferrand, 63003, France

  • CHUM

    Montreal, H2X 3E4, Canada

  • Cardioangiologisches Centrum am Bethanien Krankenhaus

    Frankfurt, 60389, Germany

  • Cardiovascular Institute of the South

    Houma, Louisiana, 70361, United States

  • Center Inselspital Bern

    Bern, 3010, Switzerland

  • Central DuPage Hospital

    Winfield, Illinois, 60190, United States

  • Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi

    Lodz, 92-213, Poland

  • Chiba University

    Chiba, Chiba, 260-8677, Japan

  • Cooper University Hospital

    Camden, New Jersey, 08103, United States

  • Emory University Hospital

    Atlanta, Georgia, 30322, United States

  • Erlanger Medical Center

    Chattanooga, Tennessee, 37403, United States

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, 100 34, Czechia

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150, Australia

  • Fondazione Toscana Gabriele Monasterio

    Massa, 54100, Italy

  • Heart Center Research, LLC

    Huntsville, Alabama, 35801, United States

  • Heart Rhythm Associates

    Shenandoah, Texas, 77380, United States

  • Helios Klinikum Siegburg

    Siegburg, 53721, Germany

  • Hightower Clinical

    Oklahoma City, Oklahoma, 73102, United States

  • Hopital Haut Leveque

    Pessac, 33604, France

  • Hospital Clinic I Provincial de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clinico San Carlos

    Madrid, Madrid, Spain

  • Hospital Universitario de Salamanca

    Salamanca, 37007, Spain

  • Hospital de la Santa Creu I Sant Pau

    Barcelona, 08025, Spain

  • Huntington Memorial Hospital

    Pasadena, California, 91109, United States

  • Institut de Cardiologie de Montreal (Montreal Heart Inst.)

    Montreal, H1T 1C8, Canada

  • Institute Cardio. Paris-Sud - Institut Jacques Cartier

    Massy, 91300, France

  • Institute of Science Tokyo Hospital

    Tokyo, Tokyo, 113-8519, Japan

  • Internistisches Klinikum München SUD

    Munich, 81379, Germany

  • Jackson Heart Clinic

    Jackson, Mississippi, 39216, United States

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, 90027, United States

  • Kansas City Cardiac Arrhythmia Research Foundation

    Overland Park, Kansas, 66211, United States

  • Kansas University Medical Center

    Kansas City, Kansas, 66160, United States

  • Klinikum der Justus-Liebig-Universität

    Giessen, 35392, Germany

  • Kokura Memorial Hospital

    Kitakyushu, Fukuoka, 802-8555, Japan

  • Kurashiki Central Hospital

    Kurashiki-shi, Okayama-ken, Japan

  • Lutheran Hospital of Indiana

    Fort Wayne, Indiana, 46801, United States

  • MedStar Union Memorial Hospital

    Baltimore, Maryland, 21218, United States

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Memorial Hermann Hospital

    Houston, Texas, 77030, United States

  • Memorial Katy Cardiology Associates

    Houston, Texas, 77094, United States

  • Mercy Medical Group - Cardiology

    Sacramento, California, 95819, United States

  • Methodist Texsan Hospital

    San Antonio, Texas, 78201, United States

  • Mission Health & Hospitals

    Asheville, North Carolina, 28801, United States

  • Monongalia General Hospital

    Morgantown, West Virginia, 26505, United States

  • Mount Sinai Hospital

    New York, New York, 10019, United States

  • Mutualiste Montsouris

    Paris, 75014, France

  • NC Heart & Vascular Research

    Raleigh, North Carolina, 27607, United States

  • NCH Healthcare System

    Naples, Florida, 34102, United States

  • Nemocnice Na Homolce

    Prague, 150 30, Czechia

  • New Mexico Heart Institute

    Albuquerque, New Mexico, 87102, United States

  • New York Presbyterian Hospital/Cornell University

    New York, New York, 10021, United States

  • Northside Hospital

    Atlanta, Georgia, 30342, United States

  • Northside Hospital (CardioVascular Group Lawrenceville)

    Lawrenceville, Georgia, 30045, United States

  • Northwestern Memorial Hospital

    Chicago, Illinois, 60611, United States

  • Oklahoma Heart Institute at Utica

    Tulsa, Oklahoma, 74104, United States

  • Ospedale San Raffaele

    Milan, 20132, Italy

  • Ottawa Heart Institute

    Ottawa, Ontario, K1Y 4W7, Canada

  • Our Lady of the Lake Physician Group

    Baton Rouge, Louisiana, 70808, United States

  • Overland Park Mid America Cardiology

    Overland Park, Kansas, 66211, United States

  • Park Plaza Hospital

    Houston, Texas, 77004, United States

  • Piedmont Heart Institute

    Atlanta, Georgia, 30309, United States

  • Pinnacle Health System

    Harrisburg, Pennsylvania, 17105, United States

  • Prince of Wales Hospital

    Hong Kong, 999077, Hong Kong

  • Queen Elizabeth Hospital

    Hong Kong, Hong Kong

  • Rigshospitalet

    Copenhagen, 2100, Denmark

  • Roper Hospital

    Charleston, South Carolina, 29401, United States

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Sanford USD Medical Center

    Sioux Falls, South Dakota, 57117, United States

  • Sarasota Memorial Hospital

    Sarasota, Florida, 34239, United States

  • Scripps Health

    La Jolla, California, 92037, United States

  • Segeberger Kliniken GmbH

    Bad Segeberg, 23795, Germany

  • Sendai Kousei Hospital

    Sendai, Miyagi, 980-0973, Japan

  • Sentara Norfolk General Hospital

    Norfolk, Virginia, 23507, United States

  • Shonan Kamakura General Hospital

    Kamakura, Kanagawa, 247-8533, Japan

  • Skejby University Hospital

    Aarhus, 8200, Denmark

  • Slaskie Centrum Chorob Serca

    Zabrze, 41-800, Poland

  • South Denver Cardiology Associates PC

    Littleton, Colorado, 80120, United States

  • South Shore University Hospital-Northwell

    Bay Shore, New York, 11706, United States

  • Spectrum Health Butterworth Hospital

    Grand Rapids, Michigan, 49503, United States

  • St. Antonius Ziekenhuis

    Nieuwegein, 3435 CM, Netherlands

  • St. Cloud Hospital - Central MN Heart Clinic

    Saint Cloud, Minnesota, 56303, United States

  • St. Joseph's Hospital

    Atlanta, Georgia, 30342, United States

  • St. Marien-Hospital-Bonn

    Bonn, 53115, Germany

  • St. Vincent Hospital

    Indianapolis, Indiana, 46240, United States

  • St. Vincent's Medical Center

    Jacksonville, Florida, 32204, United States

  • Stadtspital Triemli

    Zurich, 8063, Switzerland

  • Staten Island University Hospital Northwell

    Staten Island, New York, 10305, United States

  • Tennova Healthcare-Turkey Creek Medical Center

    Knoxville, Tennessee, 37920, United States

  • Texas Cardiac Arrhythmia

    Austin, Texas, 78705, United States

  • The Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • The Heart Hospital Baylor Plano

    Plano, Texas, 75093, United States

  • The Methodist Hospital

    Houston, Texas, 77030, United States

  • The Royal Sussex County Hospital

    Brighton, BN25BE, United Kingdom

  • The University of Hong Kong (Queen Mary Hospital)

    Hong Kong, Hong Kong

  • Toho University Ohashi Medical Center

    Meguro-ku, Tokyo, 153-8515, Japan

  • Toyohashi Heart Center

    Toyohashi, Aichi-ken, 441-8530, Japan

  • TriHealth Bethesda North Hospital

    Cincinnati, Ohio, 45242, United States

  • Tucson Medical Center

    Tucson, Arizona, 85712, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • UAMS Medical Center

    Little Rock, Arkansas, 72205, United States

  • University Hospital - Univ. of Alabama at Birmingham (UAB)

    Birmingham, Alabama, 35249, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Tsukuba Hospital

    Tsukuba, Ibaraki, 305-8576, Japan

  • Universitätsklinikum Schleswig-Holstein - Campus Lübeck

    Lübeck, Schleswig-Holstein, 23562, Germany

  • Universitätsmedizin Berlin - Campus Benjamin Franklin (CBF)

    Berlin, Brandenburg, 12203, Germany

  • Universitätsmedizin der Johannes Gutenberg-Universität Mainz

    Mainz, 55131, Germany

  • VA Medical Center Minneapolis

    Minneapolis, Minnesota, 55417, United States

  • Vancouver General Hospital (U of BC)

    Vancouver, V5Z 1M9, Canada

  • Vanderbilt Heart & Vascular Institute

    Nashville, Tennessee, 37232, United States

  • Via Christi Regional Medical Center - St. Francis Campus

    Wichita, Kansas, 67214, United States

  • Vilnius University Hospital Santariskiu Klinikos

    Vilnius, 08661, Lithuania

  • WellSpan Health

    York, Pennsylvania, 17403, United States

Conditions

Explore the condition pages connected to this study.