Could a common pill protect stroke survivors from another stroke?

NCT ID NCT04760717

Ongoing Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Researchers measure home blood pressure after 3 months to see if the drug makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Spironolactone
What this could lead to: If it works, this could point toward a better way to manage blood pressure after a stroke, potentially reducing the risk of another stroke.
What could go wrong: This is a small, early-phase trial. Spironolactone may not lower blood pressure more than standard treatments, and it can cause side effects like high potassium levels.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intracerebral hemorrhage ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRACEREBRAL HEMORRHAGE ISCHEMIC STROKE SPIRONOLACTONE

Contacts and locations

Locations

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States
Yale New Haven Hospital

New Haven, Connecticut, 06512, United States

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