Could a daily pill replace eye injections for diabetic macular edema?

NCT ID NCT06962839

Recruiting now Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 4 times

Summary

This study tests an oral medication called BI 1815368 in 300 adults with center-involved diabetic macular edema, a common cause of vision loss in diabetes. Participants take tablets twice daily for about 11 months, and doctors compare vision changes between those on the drug and those on placebo. The goal is to see if the pill can improve eyesight and find the best dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BI 1815368 (oral tablet)
What this could lead to: If it works, this could provide a convenient oral treatment option for diabetic macular edema, potentially reducing the need for frequent eye injections.
What could go wrong: This is an early Phase 2 trial with a placebo group, so the drug may not improve vision or could cause side effects. Results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

diabetic macular edema Macular Edema macular retinal edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MACULAR EDEMA

Contacts and locations

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Locations

Advanced Research Institute
RECRUITING

Pompano Beach, Florida, 33064, United States
Arizona Retina & Vitreous Research, Central Phoenix
NOT_YET_RECRUITING

Phoenix, Arizona, 85016, United States
Asahikawa Medical University Hospital
RECRUITING

Asahikawa-shi, 078-8510, Japan
Associated Vitreoretinal and Uveitis Consultants
RECRUITING

Carmel, Indiana, 46032, United States
Augenzentrum am St. Franziskus-Hospital Münster
RECRUITING

Münster, 48145, Germany
Austin Clinical Research, LLC
RECRUITING

Austin, Texas, 78750, United States
Austin Research Center for Retina, PLLC
RECRUITING

Austin, Texas, 78705, United States
Austin Retina Associates
RECRUITING

Austin, Texas, 78705, United States
Axon Clinical s.r.o.
RECRUITING

Prague, 150 00, Czechia

Contact Email: •••••@•••••
Budapest Retina Associations Kft.
RECRUITING

Budapest, 1133, Hungary
Budapesti Bajcsy-Zsilinszky Korhaz es Rendelointezet
RECRUITING

Budapest, 1106, Hungary
Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet
NOT_YET_RECRUITING

Budapest, 1204, Hungary
Caminomed Sp. z o.o.
RECRUITING

Tarnowskie Góry, 42-600, Poland
Center for Retina and Macular Disease
RECRUITING

Winter Haven, Florida, 33880, United States
Central Hospital of Northern Pest - Military Hospital
RECRUITING

Budapest, 1068, Hungary
Centrum Diagnostyki i Mikrochirurgii Oka-Lens Sp. z o.o.
RECRUITING

Olsztyn, 10-424, Poland
Centrum Medyczne Dietla 19 Sp. z o.o.
RECRUITING

Krakow, 31-070, Poland
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Clinical Medical Research Sp. z o.o.
RECRUITING

Katowice, 40-156, Poland
Colorado Retina Associates
RECRUITING

Lakewood, Colorado, 80228, United States
Cumberland Valley Retina Consultants
RECRUITING

Hagerstown, Maryland, 21740, United States
Doheny Eye Center UCLA Arcadia
RECRUITING

Pasadena, California, 91103, United States
East Florida Eye Institute
NOT_YET_RECRUITING

Stuart, Florida, 34994, United States
Eb Group Sp. z o.o.
RECRUITING

Warsaw, 00-189, Poland
Eye Research Foundation
NOT_YET_RECRUITING

Newport Beach, California, 92663, United States
F D Roosevelt University General Hospital Of Banska Bystrica
RECRUITING

Banská Bystrica, 974 01, Slovakia
Fakultna nemocnica Trencin
RECRUITING

Trenčín, 911 01, Slovakia
Fakultna nemocnica s poliklinikou Zilina
RECRUITING

Žilina, 101 01, Slovakia
Fakultni Thomayerova nemocnice
RECRUITING

Prague, 140 59, Czechia

Contact Email: •••••@•••••
Fakultni nemocnice Kralovske Vinohrady
RECRUITING

Prague, 100 00, Czechia

Contact Email: •••••@•••••
Florida Retina Institute, Jacksonville Southside
NOT_YET_RECRUITING

Jacksonville, Florida, 32216, United States
Frimley Park Hospital
RECRUITING

Camberley, GU16 7UJ, United Kingdom
Gloucestershire Royal Hospital
RECRUITING

Gloucester, GL1 3NN, United Kingdom
Juntendo University Urayasu Hospital
RECRUITING

Urayasu-shi, 279-0021, Japan
Kagawa University Hospital
RECRUITING

Kita-gun, 761-0793, Japan
King's College Hospital
RECRUITING

London, SE5 9RS, United Kingdom
Kurume University Hospital
RECRUITING

Kurume-shi, 830-0011, Japan
Medical Center Ophthalmology Associates
NOT_YET_RECRUITING

San Antonio, Texas, 78240, United States
Mid Atlantic Retina - Bethlehem
NOT_YET_RECRUITING

Bethlehem, Pennsylvania, 18017, United States
Moorfields Eye Hospital
RECRUITING

London, EC1V 2PD, United Kingdom
Nagoya City University Hospital
RECRUITING

Nagayoga, 467-8602, Japan
National Hospital Organization Tokyo Medical Center
RECRUITING

Meguro-ku, 152-8902, Japan
Nemocnica s poliklinikou Trebisov a.s.
RECRUITING

Trebišov, 075 01, Slovakia
North Carolina Retina Associates
RECRUITING

Wake Forest, North Carolina, 27587, United States
Northwick Park Hospital
RECRUITING

Harrow, HA1 3UJ, United Kingdom
Nozologen Kft.
RECRUITING

Pécs, 7621, Hungary
Oculomedica Sp. z o.o.
RECRUITING

Bydgoszcz, 85-157, Poland
Oftex s.r.o.
RECRUITING

Pardubice, 530 02, Czechia

Contact Email: •••••@•••••
Piedmont Eye Center
NOT_YET_RECRUITING

Lynchburg, Virginia, 24502, United States
Poznanskie Centrum Wzroku sp z o o
RECRUITING

Poznan, 60-538, Poland
Retina Associates of Southern California
RECRUITING

Huntington Beach, California, 92647, United States
Retina Center Of Texas
RECRUITING

Southlake, Texas, 76092, United States
Retina Consultants of San Diego
RECRUITING

Poway, California, 92064, United States
Retina Consultants of Texas
RECRUITING

The Woodlands, Texas, 77384, United States
Retina Group of Florida - Fort Lauderdale Retina Center
NOT_YET_RECRUITING

Fort Lauderdale, Florida, 33308, United States
Retina Vitreous Associates of Florida
NOT_YET_RECRUITING

St. Petersburg, Florida, 33711, United States
Retinal Consultants Medical Group, Inc
RECRUITING

Modesto, California, 95356, United States
Royal Liverpool University Hospital
RECRUITING

Liverpool, L7 8XP, United Kingdom
Royal Victoria Infirmary
RECRUITING

Newcastle upon Tyne, NE1 4LP, United Kingdom
Shanghai General Hospital
RECRUITING

Shanghai, 200080, China
Shanxi Eye Hospital
RECRUITING

Taiyuan, 030072, China
Shijiazhuang People's Hospital
RECRUITING

Shijiazhuang, 050011, China
Shinshu University Hospital
RECRUITING

Matsumoto-shi, 390-8621, Japan
Sierra Eye Associates
RECRUITING

Reno, Nevada, 89502, United States
Southend University Hospital
RECRUITING

Westcliff-on-Sea, SS0 0RY, United Kingdom
Sunderland Eye Infirmary
RECRUITING

Sunderland, SR2 9HP, United Kingdom
Szpital Sw. Rozy Sp. z o.o.
RECRUITING

Krakow, 30-394, Poland
Szpital Swietego Lukasza S. A.
RECRUITING

Bielsko-Biala, 43-309, Poland
Tennessee Retina
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Retina Associates
RECRUITING

Dallas, Texas, 75231, United States
The Fourth People's Hospital of Shenyang
RECRUITING

Shenyang, 110031, China
Tokyo Medical University Hachioji Medical Center
RECRUITING

Hachioji-shi, 193-0998, Japan
Tokyo Women's Medical University Hospital
RECRUITING

Tokyo, 162-8666, Japan
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Dresden, 01307, Germany
University Hospital Hradec Kralove (FNHK)
RECRUITING

Hradec Králové, 500 03, Czechia

Contact Email: •••••@•••••
University Hospital Ostrava
RECRUITING

Ostrava-Poruba, 708 52, Czechia

Contact Email: •••••@•••••
University of Debrecen
RECRUITING

Debrecen, 4032, Hungary
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Pecs
RECRUITING

Pécs, 7623, Hungary
University of Szeged
RECRUITING

Szeged, 6720, Hungary
Universitätsklinikum Düsseldorf
RECRUITING

Düsseldorf, 40225, Germany
Universitätsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitätsklinikum Mannheim GmbH
RECRUITING

Mannheim, 68167, Germany
Verum Research, LLC
RECRUITING

Eugene, Oregon, 97401, United States
Vseobecna fakultni nemocnice v Praze
RECRUITING

Prague, 128 00, Czechia

Contact Email: •••••@•••••
Warszawski Szpital Okulistyczny Sp. z o.o.
RECRUITING

Warsaw, 01-258, Poland
West China Hospital, Sichuan University
RECRUITING

Chengdu, 610041, China
West Coast Retina Medical Group, Inc.
RECRUITING

San Francisco, California, 94109, United States
Win Retina
RECRUITING

Arcadia, California, 91006, United States

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