Can Clot-Busters overcome blood thinners to save brains?

NCT ID NCT06571149

Recruiting now Disease control Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial investigates whether giving clot-busting drugs (tenecteplase or alteplase) to people who have an ischemic stroke while taking direct oral anticoagulants (blood thinners) is safe and effective. About 906 adults who had a stroke within 48 hours of taking a DOAC will be randomly assigned to receive either the clot-buster plus standard care, or standard care alone. The goal is to see if the clot-buster improves recovery at 90 days compared to standard treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tenecteplase or Alteplase (clot-busting drugs given intravenously)
What this could lead to: If successful, this could expand stroke treatment options for patients on blood thinners, potentially improving recovery and reducing disability.
What could go wrong: The trial is still testing safety and efficacy; there is a risk of bleeding, and results may not confirm benefit in this specific patient group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ISCHEMIC STROKE

Contacts and locations

Locations

"Attikon" University Hospital
NOT_YET_RECRUITING

Athens, 12462, Greece
2nd Department of Neurology, School of Medicine Faculty of Health Sciences, Aristotle University of Thessaloniki
NOT_YET_RECRUITING

Thessaloniki, 546 36, Greece
AP-HP, Lariboisière
NOT_YET_RECRUITING

Paris, 75019, France
AP-HP, Pitié-Salpêtrière
NOT_YET_RECRUITING

Paris, 75013, France
AZ Groeninge, Campus Kennedy
RECRUITING

Kortrijk, Belgium
AZ Sint-Jan Brugge AV
RECRUITING

Bruges, Belgium
Academic Medical Center Amsterdam, Department of Neurology
RECRUITING

Amsterdam, 1105, Netherlands
Akershus Hospital
RECRUITING

Oslo, Norway
Albert Schweitzer ziekenhuis
NOT_YET_RECRUITING

Dordrecht, 3318, Netherlands
Alfried Krupp Krankenhaus
NOT_YET_RECRUITING

Essen, 45131, Germany
Amphia Hospital
RECRUITING

Breda, 4818, Netherlands
Asklepios Klinik Barmbek
NOT_YET_RECRUITING

Hamburg, 22307, Germany
Asklepios Klinik Wandsbek
RECRUITING

Hamburg, Germany
Barmherzige Brüder Krankenhaus Eisenstadt
RECRUITING

Eisenstadt, 7000, Austria
Barmherzige Brüder Krankenhaus Wien
RECRUITING

Vienna, 1020, Austria
CHU Bordeaux
NOT_YET_RECRUITING

Bordeaux, 33000, France
CHU Montpellier
NOT_YET_RECRUITING

Montpellier, 34 295, France
CHU Nancy
NOT_YET_RECRUITING

Nancy, 54035, France
CHU de Lille
NOT_YET_RECRUITING

Lille, 59037, France
CHU de Liège
NOT_YET_RECRUITING

Liège, 4000, Belgium
Catharina Ziekenhuis
NOT_YET_RECRUITING

Eindhoven, 5623, Netherlands
Christian Doppler Klinik
RECRUITING

Salzburg, 5020, Austria
Chu Grenoble Alpes
NOT_YET_RECRUITING

Grenoble, 38043, France
Cliniques Universitaires de Bruxelles
RECRUITING

Brussels, Belgium
Department of Neurology University Hospital of Alexandroupolis Democritus University of Thrace
NOT_YET_RECRUITING

Alexandroupoli, 68100, Greece
Department of Neurology, School of Medicine University of Crete
NOT_YET_RECRUITING

Heraklion, 71500, Greece
Eginition Hospital
NOT_YET_RECRUITING

Athens, 11528, Greece
Ente Ospedaliero Cantonale Istituto di Neuroscienze Cliniche della Svizzera Italiana Stroke Center EOC, Clinica di Neurologia c/o Ospedale Regionale di Lugano, sede Civico
NOT_YET_RECRUITING

Lugano, 6903, Switzerland
Erasmus Medical Center
NOT_YET_RECRUITING

Rotterdam, 3015, Netherlands
Franciscus Gasthuis
NOT_YET_RECRUITING

Rotterdam, 3045, Netherlands
GHU Paris Psychiatrie et Neurosciences, Sainte Anne
RECRUITING

Paris, 75014, France
Haaglanden MC, HMC Westeinde
RECRUITING

The Hague, 2512, Netherlands
Haga Ziekenhuis
RECRUITING

The Hague, 6815, Netherlands
Hamilton Health Sciences
NOT_YET_RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Heidelberg University Hospital
RECRUITING

Heidelberg, 69120, Germany
Helios Klinik Schleswig GmbH, Klinik für Neurologie und Neurologische
RECRUITING

Schleswig, Germany
Helios Klinikum Erfurt GmbH
RECRUITING

Erfurt, 99089, Germany
Helsinki University Central Hospital
RECRUITING

Helsinki, 00290, Finland
Hospitais da Universidade de Coimbra
NOT_YET_RECRUITING

Coimbra, 3004-561, Portugal
Hospital Amadora-Sintra Fernando Fonseca
NOT_YET_RECRUITING

Amadora, 2720-276, Portugal
Hospital Dr. Nélio Mendonça
RECRUITING

Funchal, 9000-177, Portugal
Hospital Egas Moinz
RECRUITING

Lisbon, 1449-005, Portugal
Hospital Pedro Hispano
RECRUITING

Matosinhos Municipality, 4464-513, Portugal
Hospital de Santo António
RECRUITING

Porto, 4099-001, Portugal
Hospital de São João
RECRUITING

Porto, 4200-319, Switzerland
Hôpital Civil Marie Curie
RECRUITING

Charleroi, Belgium
Hôpital FOCH
NOT_YET_RECRUITING

Suresnes, 92150, France
Hôpital Paris Saint-Joseph
NOT_YET_RECRUITING

Paris, 75014, France
Hôpital Pierre Wertheimer
NOT_YET_RECRUITING

Lyon, 69677, France
Hôpital de Hautepierre
NOT_YET_RECRUITING

Strasbourg, 67098, France
Hôpitaux Universitaires Genève
RECRUITING

Geneva, 1205, Switzerland
Inselspital Bern
RECRUITING

Bern, 3010, Switzerland
Isala Hospital
NOT_YET_RECRUITING

Zwolle, 8025, Netherlands
Kantonsspital Baden AG
RECRUITING

Baden, 5404, Switzerland
Kantonsspital St. Gallen
RECRUITING

Sankt Gallen, Switzerland
Klinik Hirslanden
NOT_YET_RECRUITING

Zurich, 8032, Switzerland
Klinikum Kassel
RECRUITING

Kassel, 34125, Germany
Klinikum der Stadt Ludwigshafen
RECRUITING

Ludwigshafen, Germany
Klinikum der Universität München
RECRUITING

München, 81377, Germany
Knappschaft Kliniken Bottrop GmbH
RECRUITING

Bottrop, 46242, Germany
Lisbon Central University Hospital Centre
RECRUITING

Lisbon, 1150-199, Portugal
Luzerner Kantonsspital
RECRUITING

Lucerne, 6000, Switzerland
MEDIN La Tour
RECRUITING

Biel, 2502, Switzerland
Medical University of Innsbruck
NOT_YET_RECRUITING

Innsbruck, 6020, Austria
Medizinische Universität Wien
RECRUITING

Vienna, 1090, Austria
Médecin Associé Service de Neurologie Département des Neurosciences Cliniques CHUV, BH13
RECRUITING

Lausanne, 1011, Switzerland
Neurologue FMH, AFC EEG/ENMG
RECRUITING

Nyon, 1260, Switzerland
Nordwest-Krankenhaus Sanderbusch
RECRUITING

Sande, 26452, Germany
OLVG location East
NOT_YET_RECRUITING

Amsterdam, 1091, Netherlands
Perpignan Hospital Center
NOT_YET_RECRUITING

Perpignan, 66000, France
RHÖN-KLINIKUM AG - Campus Bad Neustadt
RECRUITING

Bad Neustadt an der Saale, 97616, Germany
Radboud University Nijmegen Medical Center
RECRUITING

Nijmegen, 6500, Netherlands
Rijnstate
RECRUITING

Arnhem, 6815, Netherlands
RoMed Klinikum Rosenheim Klinik
NOT_YET_RECRUITING

Rosenheim, 83022, Germany
SRH Klinikum Karlsbad-Langensteinbach GmbH
RECRUITING

Karlsbad, Baden-Wurttemberg, 76307, Germany
Sana Kliniken Lübeck GmbH
NOT_YET_RECRUITING

Lübeck, 23560, Germany
Sozialstiftung Bamberg
NOT_YET_RECRUITING

Bamberg, 96049, Germany
St. Antonius Ziekenhuis
NOT_YET_RECRUITING

Nieuwegein, 3435, Netherlands
St. Josef-Hospital
RECRUITING

Bochum, 44791, Germany
Stadtspital Zürich
RECRUITING

Zurich, 8063, Switzerland
UCL St Luc
RECRUITING

Brussels, Belgium
ULS de Entre Douro e Vouga
RECRUITING

Porto, 4520-211, Portugal
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
University General Hospital of Patras
NOT_YET_RECRUITING

Pátrai, 265 04, Greece
University Hospital Basel
RECRUITING

Basel, 4031, Switzerland
University Hospital Gent
RECRUITING

Ghent, Belgium
University Medical Center
RECRUITING

Leiden, 2333, Netherlands
University Medical Center
NOT_YET_RECRUITING

Maastricht, 6229, Netherlands
University Medical Center Groningen
RECRUITING

Groningen, 9700, Netherlands
University Medical Center Utrecht
RECRUITING

Utrecht, 3584, Netherlands
Universität Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitätsklinik für Neurologie Graz
RECRUITING

Graz, 8036, Austria
Universitätsklinikum Freiburg
RECRUITING

Freiburg im Breisgau, 79106, Germany
Universitätsklinikum Gießen und Marburg GmbH
RECRUITING

Giessen, Germany
Universitätsklinikum Jena
RECRUITING

Jena, 07747, Germany
Universitätsklinikum Tübingen, Abt. Neurologie mit Schwerpunkt neurovaskuläre Erkrankungen
RECRUITING

Tübingen, Germany
Universitätsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
Universitätsklinikum des Saarlandes
NOT_YET_RECRUITING

Homburg, 66421, Germany
Universitätsmedizin Frankfurt
RECRUITING

Frankfurt, 60590, Germany
Universitätsmedizin Göttingen, Abteilung Neurologie
RECRUITING

Göttingen, Germany
Universitätsspital Zürich
RECRUITING

Zurich, 8091, Switzerland
Vall d'Hebron Stroke Center
NOT_YET_RECRUITING

Barcelona, 08035, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.