New drug could extend window for treating deadly stroke
NCT ID NCT05105633
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial is testing a drug called tenecteplase for people with a severe stroke caused by a blockage in the basilar artery at the back of the brain. About 688 participants will receive either tenecteplase or standard care within 24 hours of symptoms starting, followed by a clot-removal procedure if needed. The goal is to see if tenecteplase helps more people recover with little or no disability at 90 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tenecteplase (a clot-busting drug given as a quick injection)
- What this could lead to
- If it works, this could offer a more effective clot-busting treatment for a severe type of stroke, potentially helping more people recover without disability.
- What could go wrong
- This is an early-to-mid stage trial, so results are not guaranteed. The drug may not improve outcomes and could increase the risk of bleeding in the brain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Alfred Health
RECRUITINGMelbourne, Victoria, Australia
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Austin Hospital
RECRUITINGMelbourne, Victoria, Australia
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Bankstown-Lidcombe Hospital
NOT_YET_RECRUITINGBankstown, New South Wales, Australia
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Box Hill Hospital
RECRUITINGMelbourne, Victoria, Australia
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Fiona Stanley Hospital
RECRUITINGMurdoch, Western Australia, 6150, Australia
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Gold Coast Hospital
NOT_YET_RECRUITINGGold Coast, Queensland, Australia
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Grampians Health
RECRUITINGBallarat, Australia
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Hospital Geral de Fortaleza
RECRUITINGFortaleza, Brazil
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John Hunter Hospital
NOT_YET_RECRUITINGNewcastle, New South Wales, Australia
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Liverpool Hospital
RECRUITINGSydney, New South Wales, Australia
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Monash Health
NOT_YET_RECRUITINGMelbourne, Victoria, Australia
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Northern Hospital
RECRUITINGMelbourne, Australia
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Princess Alexandra Hospital
RECRUITINGWoolloongabba, Queensland, 4102, Australia
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Royal Adelaide Hospital
RECRUITINGAdelaide, South Australia, Australia
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Royal Melbourne Hospital
RECRUITINGMelbourne, Victoria, Australia
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Tours University Hospital
RECRUITINGTours, France
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Western Health
RECRUITINGMelbourne, Victoria, Australia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Clot-Removal procedure turn the tide in severe stroke?
- Clot-Removal procedure may offer hope for severe brain stem strokes
- Stroke treatment showdown: is removing the clot alone enough?
- New hope for Late-Stroke patients: clot removal may work even days later
- Wrist vs groin: which artery route is best for stroke clot removal?
- New combo treatment could improve outcomes in major stroke