New combo treatment could improve outcomes in major stroke
NCT ID NCT05701956
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether giving a clot-busting drug (tenecteplase) before mechanical clot removal helps people with a severe type of stroke caused by a blockage in the basilar artery. The trial included 330 adults who were treated between 4.5 and 24 hours after stroke symptoms began. The main goal was to see if the combination led to better recovery (less disability) at 90 days compared to clot removal alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tenecteplase (a clot-busting drug)
What this could lead to
If it works, this could offer a better treatment for severe strokes by combining a clot-busting drug with mechanical clot removal.
What could go wrong
This is a completed Phase 3 trial, but results are not yet published. Adding tenecteplase may increase bleeding risk without improving outcomes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The First Affiliated Hospital of University of Science and Technology of China
Hefei, Anhui, 230001, China