Stroke treatment showdown: is removing the clot alone enough?
NCT ID NCT05827042
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two treatments for a severe type of stroke caused by a blockage in a major artery at the base of the brain. Some patients will get a clot-busting drug through a vein followed by a procedure to remove the clot, while others will have the clot removal procedure alone. The goal is to see if skipping the drug leads to similar or better recovery and safety. About 338 adults who can be treated within 4.5 hours of stroke onset will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Alteplase or Tenecteplase (clot-busting drugs given through a vein)
What this could lead to
If successful, this could show that removing the clot directly is just as good or better than giving a clot-busting drug first, potentially simplifying treatment for this severe stroke type.
What could go wrong
This is a Phase 3 trial but still relatively small (338 people). The results may not apply to all stroke patients, and there is a risk that skipping the clot-busting drug could lead to worse outcomes or more disability.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The First Affiliated Hospital of University of Science and Technology of China
RECRUITINGHefei, Anhui, 230001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••