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Stroke treatment showdown: is removing the clot alone enough?

NCT ID NCT05827042

Completed Disease control Sponsor: The First Affiliated Hospital of University of Science and Technology of China Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This study compares two treatments for a severe type of stroke caused by a blockage in a major artery at the base of the brain. Some patients will get a clot-busting drug through a vein followed by a procedure to remove the clot, while others will have the clot removal procedure alone. The goal is to see if skipping the drug leads to similar or better recovery and safety. About 338 adults who can be treated within 4.5 hours of stroke onset will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Alteplase or Tenecteplase (clot-busting drugs given through a vein)
What this could lead to
If successful, this could show that removing the clot directly is just as good or better than giving a clot-busting drug first, potentially simplifying treatment for this severe stroke type.
What could go wrong
This is a Phase 3 trial but still relatively small (338 people). The results may not apply to all stroke patients, and there is a risk that skipping the clot-busting drug could lead to worse outcomes or more disability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

basilar artery occlusion stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE CEREBROVASCULAR ACCIDENT BASILAR ARTERY OCCLUSION STROKE DUE TO BASILAR ARTERY OCCLUSION

Contacts and locations

Locations

  • The First Affiliated Hospital of University of Science and Technology of China

    Hefei, Anhui, 230001, China

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