Home leg exercises may rewire the brain after severe stroke

NCT ID NCT07652970

Recruiting now Knowledge-focused Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study explores whether exercising the unaffected leg at home can trigger beneficial brain and spinal changes in people with severe stroke. Participants perform strength and coordination tasks with their stronger leg using a tablet-based system, while researchers measure brain activity and leg function before and after. The goal is to see if this 'cross-education' approach can improve movement in the affected leg.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: home-based cross-education (unilateral skill and strength training of the unaffected leg)
What this could lead to: If it works, this approach could offer a simple, home-based therapy to improve leg function in people with severe stroke, without needing expensive equipment.
What could go wrong: This is a small, early-stage study with only 40 participants, so results may not apply to everyone. The training focuses on the unaffected leg, and benefits for the affected leg may be limited.

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STROKE

Contacts and locations

Locations

Brain Plasticity Lab
RECRUITING

Chicago, Illinois, 60612, United States

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