University Of Illinois At Chicago

This study tests whether adding a precise, targeted form of radiation to the usual chemotherapy before a stem cell transplant can kill more cancer cells in the bone marrow and lower the chance of the disease coming back. It involves 27 adults aged 18-75 with acute leukemia or mye…

This study tests a completely oral (pill-based) chemotherapy combination called CMC for people with early-stage breast cancer who have had surgery. The goal is to see if this all-oral regimen is as effective and safer than standard IV chemo. About 25 adults will take three differ…

This early-phase study tests whether adding precise radiation to up to 10 tumor spots can improve the effectiveness of immunotherapy in people with advanced solid tumors that have spread to 3-10 places. About 28 adults will receive the combination and be monitored for changes in …

This study looks at whether using smartphone health apps and receiving personalized text messages can help people with chronic heart failure manage their condition better. Researchers want to see if these tools reduce the number of days people spend in the hospital for heart prob…

This study tests whether using a tool called OncoChoice to select chemotherapy can help shrink tumors or slow their growth in people with advanced non-small cell lung cancer (NSCLC) that has spread. About 29 adults who have already tried at least one prior treatment will receive …

This study tests a stem cell transplant using a half-matched family donor for people with severe sickle cell disease. Participants receive low-dose radiation and chemotherapy before the transplant, followed by drugs to prevent rejection. The main goal is to see if the donor cells…

This study tests a natural compound from licorice root (glycyrrhizin) in 60 men with prostate cancer who are scheduled for surgery. Participants take the extract daily before their operation to see if it lowers PSA levels and is safe. The goal is to learn if this supplement can h…

This study is for people with early-stage triple-negative breast cancer who are scheduled for surgery. Before surgery, they will receive two drugs: lenvatinib (taken daily for 7 days) and one dose of pembrolizumab (given by IV). The goal is to see if this short treatment can incr…

This study tests whether a combination of two drugs, cabozantinib and pembrolizumab, can help keep advanced squamous non-small cell lung cancer from growing after initial treatment. About 36 adults whose cancer was controlled after standard chemotherapy plus pembrolizumab will re…

This study tests whether eye drops made from stem cell secretions can help heal persistent corneal defects that haven't responded to standard treatments. Twenty-four adults with chronic corneal damage will receive either the active drops or a placebo for 8 weeks. The main goal is…

This study tests whether a new therapy that combines rewards for staying sober with problem-solving skills can help young adults (ages 18-24) with alcohol use disorder quit drinking. Participants will be randomly assigned to receive the new therapy or standard rewards alone, and …

This study looks at whether people with early-stage HR+HER2- breast cancer can safely take a higher dose of the drug abemaciclib along with hormone therapy. The goal is to see if more patients can stay on the full approved dose for 84 days. About 50 participants will be enrolled,…

This study explores whether time-restricted eating (eating only during certain hours of the day) is safe and practical for pregnant women with severe obesity. About 60 women in their second and third trimesters will either follow this eating pattern or receive standard care. The …

This study aims to help Latina women who are at high risk for breast cancer get the right screening and genetic testing. Researchers will provide phone-based coaching and navigation support to 600 participants over three weeks. The goal is to see if this support helps more women …

This study tests a 12-week program for Black women who have had breast cancer and also have high blood pressure or obesity. The program includes grocery delivery, cooking classes, and nutrition education to help them eat healthier and control blood pressure. The goal is to see if…

This study tests a program to help Black adults with chronic kidney disease (CKD) reduce their sitting time. Half of the 40 participants will get support to sit less, while the other half receives general CKD education. The goal is to see if cutting down on sedentary time improve…

This study tests whether a single injection of stem cells from a donor can help heal corneal ulcers that haven't improved with standard treatments. About 38 adults with persistent eye surface damage will receive the injection and be monitored for up to 90 days. The goal is to see…

This study tests a 6-month program called PROTECT for caregivers of young children who had dental surgery. The program provides parenting tools and support from community health workers to improve tooth brushing and reduce sugar intake. The goal is to prevent future cavities and …

This study is testing whether a two-drug maintenance therapy can help control multiple myeloma in patients who still have small amounts of cancer cells after a stem cell transplant. The treatment involves regular infusions of one drug and daily pills of another, taken long-term t…

This study is testing whether sending personalized text messages can help older adults with heart failure take better care of themselves. Researchers will enroll 30 participants who will either receive about 5 supportive texts per week for 12 weeks or be in a comparison group. Th…

This study is testing whether rinsing the sinuses with a probiotic solution is more effective than a standard saltwater rinse for treating flare-ups of chronic sinusitis. It will involve 60 adults who have had sinus surgery in the past. Participants will use one of the two rinses…

This study tests a family-based program that includes Black male caregivers to help protect Black girls aged 14-18 from HIV, other sexually transmitted infections, and sexual violence. Researchers will enroll 612 participants to see if involving male caregivers reduces infection …

This study tests whether taking a probiotic called LP299V twice daily can help pregnant women at risk of iron deficiency absorb more iron from their diet. The goal is to prevent iron deficiency anemia and its serious complications, like preterm birth. Researchers will enroll 250 …

This study aims to prevent unnecessary deaths from cervical cancer in Senegal by helping more women get screened early. Researchers will adapt a patient navigation program for both urban and rural areas, addressing barriers like stigma and misinformation. About 901 women and men …

This study tests if a special treadmill training program before total knee replacement surgery can help prevent falls after the operation. Participants will be split into two groups: one gets fall-prevention information only, the other also does two weeks of treadmill perturbatio…

This study tests whether a home-based, internet-delivered physical activity program can improve cognitive processing speed (thinking speed) in people with multiple sclerosis who have mild walking difficulties. Researchers will compare the exercise program to an active control con…

This study tests whether using mild brain stimulation before walking therapy can help people who have had a stroke walk better. About 100 adults who had a stroke at least 3 months ago and still have trouble walking will take part. The goal is to see if this approach improves walk…

This study tests whether a type of talk therapy for insomnia (CBTi) can help people with type 1 diabetes sleep better and control their blood sugar. About 15 adults with type 1 diabetes and poor sleep will either get 8 virtual therapy sessions or health education emails. Research…

This study looks at whether eating all food within an 8-hour window each day is practical and helpful for people receiving chemotherapy for early-stage or advanced breast cancer. Researchers will test three different eating windows compared to a control group over 24 weeks. The g…

This study tests whether combining progressive muscle relaxation with a walking program can help reduce fatigue in adults with end-stage kidney disease who are on dialysis. About 40 participants will try the program for 12 weeks. The goal is to see if the approach is practical an…

This study looks at whether following a Mediterranean diet can help reduce chronic pain in people with sickle cell disease. Researchers will compare pain levels when participants eat the Mediterranean diet versus their usual diet. The study involves 30 adults with sickle cell dis…

This study tests a non-drug approach for people with knee osteoarthritis and low back pain. Participants will have a cuff on one thigh that briefly stops blood flow for 5 minutes at a time, repeated over 2 weeks. The goal is to see if this improves walking speed, muscle strength,…

This study tests whether a home-based balance training program can improve both physical and cognitive symptoms in people with multiple sclerosis (MS). 75 adults with MS will be randomly assigned to either the balance program or a stretching routine for 4 months. All sessions are…

This study tests whether a skin patch (granisetron) works better than a standard oral drug (ondansetron) to prevent nausea and vomiting in people getting chemotherapy before a stem cell transplant. About 90 adults aged 18-75 will take part. Both groups also receive dexamethasone.…

This study looks at whether eating only during an 8-hour window each day (time-restricted eating) can help women with breast cancer have fewer side effects and better quality of life during chemotherapy. Some participants will also follow a Mediterranean diet. The study involves …

This study tests a program that combines health coaching, motivational interviewing, and online wellness tools to help 60 adults with serious mental illness improve their health and daily functioning after major disruptions like the COVID-19 pandemic. Participants will work with …

This study tests a specially designed, at-home exercise program for African-Americans with multiple sclerosis who live in rural areas. About 100 participants will either do the exercise program or a stretching routine. The goal is to see if the program improves walking, reduces f…

This study looks at whether a specific exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Twenty-five veterans will do 90 exercise sessions over 18 m…

This study tests whether a 12-week mindful walking program can reduce stress and improve thinking skills in older South Asian family caregivers (age 45+) who care for someone with cognitive disabilities. Fifty participants will be split into two groups: one does mindful walking w…

This study looks at whether fun activities like dance and virtual reality gaming can help people who have had a stroke improve their balance, movement, and daily function. Researchers will compare these alternative therapies to standard rehabilitation in 120 adults aged 18 to 90.…

This study is testing whether taking melatonin supplements can improve sleep patterns and daily body rhythms in people with diabetic retinopathy, an eye complication of diabetes. Researchers will monitor sleep, melatonin, and cortisol levels in 42 adults aged 40-65 with type 2 di…

This study looks at whether a smartphone-based mindfulness program is practical and helpful for teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use guided mindfulness exercises on their phone for about 8 weeks. Th…

This study tests whether using a home-based electrical stimulation device along with specific exercises can improve walking, balance, and mobility in adults who had a stroke more than 6 months ago. Thirty participants will use the device at home for 12 weeks while doing task-spec…

This study looks at whether using a blood pressure cuff on the thigh can make leg muscles stronger and improve walking in people who have lost a leg. Researchers will measure strength, walking speed, and daily activity before and after the intervention. The goal is to find a simp…

This study tests whether a one-month meditation app can help 300 youth (ages 13-20) on probation in Cook County, IL, reduce cannabis use and improve emotional control. Participants use the app and report changes in substance use, sexual risk behaviors, and mood. The goal is to se…

This study is testing an artificial intelligence (AI) tool that estimates a person's chance of developing lung cancer in the next 3 years. Researchers want to see how learning this risk score affects patients' feelings, health beliefs, and whether they follow up with lung cancer …

This study is creating a digital program to help East Asian immigrants who have cancer start conversations with their family about future medical care. Researchers will test how easy and acceptable the tool is for 84 participants, including patients and religious leaders. The goa…

This study is for people with high-risk early-stage breast cancer. It tests whether taking a low dose of the drug azacitidine before surgery can increase immune cells (called TILs) inside the tumor. The goal is to see if the drug can make the immune system more active against the…

This study looks at two different ways to offer cancer genetic testing to patients at community health centers. One method lets primary care doctors order the test directly, while the other uses a standard referral with extra support. Researchers want to see which approach helps …

This study looks at how being obese changes your DNA and harms blood vessels. Researchers want to see if 12 weeks of aerobic exercise can reverse these changes. 80 adults scheduled for weight-loss surgery will take part. The goal is to understand the body's inner workings, not to…

This study is for people with multiple myeloma who have been on maintenance therapy for at least two years after a stem cell transplant. Researchers want to see if patients whose cancer is undetectable (MRD-negative) can safely stop taking their daily medication without the cance…

This study tests a new way to find people with undiagnosed HIV in South Africa. Instead of only asking people to bring in their sexual partners, the program asks people who just learned they have HIV to invite anyone they know who might benefit from testing. The goal is to reach …

This study looks at why people who had a stroke have trouble coordinating their legs while walking. Researchers will measure brain and nerve signals in 50 adults with chronic stroke to find the root causes. The goal is to gather knowledge that could lead to better walking therapi…

This study tests whether an artificial intelligence (AI) tool called Sybil can better predict lung cancer risk and help expand screening to more people. Researchers will enroll 2,500 adults aged 50-80 who are already getting lung scans. The goal is to see if AI and broader guidel…

This study looks at whether a program called Coffee and Family Education and Support (CAFES2) helps refugee families from Arabic-speaking countries feel less depressed, anxious, or stressed. About 74 families in Chicago will take part. The program is led by trained peers and focu…

This study collects spinal cord and brain tissues, along with MRI scans, from 40 adults with ALS after they pass away. The goal is to find biological markers that show how the disease progresses. By linking imaging data with genetic and tissue changes, researchers hope to better …

This study aims to reduce stigma and increase access to harm reduction services for people who use opioids on Chicago's West side. Researchers will train 600 non-drug-using friends and family members to become harm reduction champions, providing them with tools like naloxone and …

This study looks at whether analyzing waste from surgical suction devices can help detect brain tumor cells during surgery. Currently, surgeons use a special dye and a fluorescent light to see tumors, but some cells can be missed. The study will include 8 adults having brain tumo…

This study tests a free rideshare program (like Uber or Lyft) for 60 people with diabetic retinopathy who have Medicaid insurance. The goal is to see if offering free rides helps patients attend their scheduled eye appointments. Researchers will compare attendance rates before an…