University Of Illinois At Chicago

This phase II trial tests whether adding targeted total marrow irradiation to standard chemotherapy before a stem cell transplant can improve outcomes for people with high-risk acute myeloid leukemia, chronic myeloid leukemia, or myelodysplastic syndromes. The study will enroll 3…

This study tests whether slowly increasing the dose of the drug abemaciclib over three weeks helps patients with early-stage HR+HER2- breast cancer stay on the full approved dose. About 50 participants will receive the drug alongside hormone therapy. The main goal is to see if mo…

This study tests a temporary magnetic device designed to help people with paralytic lagophthalmos—a condition where the eyelid cannot close fully—protect their eyes from dryness, ulcers, and vision loss. The device uses small magnets placed on the eyelids to gently hold them shut…

This study tests whether empagliflozin, a drug already approved for kidney disease in diabetes, can slow kidney damage in people with sickle cell anemia. About 20 adults with sickle cell disease and early signs of kidney trouble will take the drug for 6 months. Researchers will m…

This study tests whether a mild brain stimulation technique called tDCS, combined with treadmill training, can improve walking in people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months past their first stroke and have trouble walking. The goal …

This study tests a new behavioral therapy called CM-PST, designed to help young adults (ages 18-24) with alcohol use disorder achieve and maintain abstinence. The therapy combines rewards for abstinence with skills to manage daily challenges. The trial first checks if the therapy…

This study tests whether adding a precise, targeted form of radiation to the standard chemotherapy and stem cell transplant can kill more cancer cells in the bone marrow and reduce the chance of relapse. About 27 adults with acute leukemia or myelodysplastic syndrome (MDS) will r…

This study tests whether a 1-month meditation app can help youth on probation (ages 13-20) reduce cannabis use and risky sexual behaviors by improving emotion regulation. Researchers will enroll 300 participants in Cook County, IL, and measure changes in substance use, mood, and …

This pilot study tests whether giving precise, high-dose radiation to all visible tumors (up to 10) can improve the effectiveness of immunotherapy in people with advanced solid tumors that have spread. About 28 adults with 3-10 metastases will receive radiation over 3 weeks while…

This study tests a free rideshare program (PRONTO-EYE) to help diabetic retinopathy patients with Medicaid get to their eye appointments. Researchers will see if offering transportation helps patients attend visits more regularly. The pilot includes 60 English-speaking adults who…

This study tests a program to help Black adults with chronic kidney disease (CKD) reduce their daily sitting time. Half of the 40 participants will receive support to sit less, while the other half will get general CKD education. The goal is to see if cutting down on sitting can …

This phase 2 trial tests whether a combination of two drugs, isatuximab and lenalidomide, can clear remaining cancer cells in multiple myeloma patients who still have minimal residual disease (MRD) after an autologous stem cell transplant. About 50 adults will receive the drugs a…

This study tests whether a compound from licorice root, called glycyrrhizin, can reduce PSA levels in men with prostate cancer before they have surgery to remove the prostate. About 60 men who are scheduled for prostate removal will take glycyrrhizin daily for a short time. The g…

This study tests whether eye drops made from stem cell secretions can help heal persistent corneal defects that haven't improved with standard treatments. About 24 adults with chronic corneal damage will receive either the active drops or a placebo for 8 weeks. The main goal is t…

This phase II trial is testing a stem cell transplant from a half-matched donor for people with severe sickle cell disease. Participants receive chemotherapy, radiation, and immune-suppressing drugs before the transplant to help the new cells take hold. The main goal is to see if…

This pilot study will test whether time-restricted eating (eating only during an 8-10 hour window each day) is safe and feasible for pregnant women with severe obesity. Sixty women in their second or third trimester will either follow this eating pattern or receive standard care.…

This study tests a personalized approach to chemotherapy for people with advanced non-small cell lung cancer (NSCLC) that has spread. Participants have already tried at least one other treatment. The goal is to see if using a tool called OncoChoice to pick the right chemo improve…

This study tests whether combining two drugs (cabozantinib and pembrolizumab) as ongoing treatment can help keep advanced squamous lung cancer from growing. It is for people whose cancer was controlled after initial chemotherapy plus immunotherapy. About 36 adults will participat…

This study tests a completely oral (pill-based) chemotherapy combination called CMC for people with early-stage breast cancer who have had surgery. The goal is to see if this all-oral regimen is as effective and safer than standard IV chemo. About 25 adults will take three differ…

This pilot study is testing whether multiple myeloma patients who have no detectable cancer cells (called MRD-negative) after a stem cell transplant can safely stop their daily maintenance drugs. Fifty participants will be followed closely with bone marrow tests to see if their c…

This study tests whether injecting stem cells into the eye can help heal corneal ulcers that haven't improved with standard treatments. The stem cells are donated from healthy volunteers and processed in a lab. About 38 adults with persistent eye surface damage will receive the i…

This early-phase trial is testing whether giving two drugs—lenvatinib and pembrolizumab—before surgery can boost the immune response in people with early-stage triple-negative breast cancer. Only 12 participants will receive the short treatment before their planned surgery. The m…

This study tests a 12-week program for African-American women who have had breast cancer and now have high blood pressure or obesity. The program provides grocery delivery, cooking classes, and nutrition education to help them eat healthier and control their blood pressure. The g…

This study is testing whether an artificial intelligence tool called Sybil can improve lung cancer screening by better predicting who is at risk. Researchers will analyze low-dose CT scans from 2,500 people aged 50-80 and compare AI results with current screening guidelines. The …

This study is testing whether an artificial intelligence (AI) blood test and risk model can help find lung cancer early in people at high risk. Researchers will enroll 400 adults aged 50-80 who smoke or recently quit. Some will get the AI blood test, others an AI analysis of thei…

This study tests a patient navigation program to help women in Senegal overcome barriers to cervical cancer screening and follow-up care. Researchers will work with community health workers to guide women through the process, addressing stigma and misinformation. The goal is to i…

This study tests whether a probiotic called LP299V can help pregnant women at risk of iron deficiency absorb more iron from their diet. Researchers will give 250 women either the probiotic or a placebo from early pregnancy until labor. The goal is to see if the probiotic improves…

This study tests whether teaching Black male caregivers how to talk about sexual health can help protect Black girls aged 14-18 from HIV, other sexually transmitted infections, and sexual violence. The program involves 612 pairs of girls and their male caregivers. Researchers wil…

This study tests whether clemastine, a common antihistamine, can improve brain white matter and make antidepressants work better for adults over 60 with depression. Eighty participants will receive either clemastine or a placebo alongside their antidepressant. The goal is to see …

This pilot study tests whether a 36-session targeted exercise program can help frail pancreatic cancer patients stay stronger and complete their chemotherapy with fewer problems. Researchers will enroll 25 patients who are frail or pre-frail and receiving chemotherapy before surg…

This study tests a program called ROCKS that helps people with advanced cancer and their family caregivers build optimism, communication skills, and knowledge to discuss advance care planning. 152 patient-caregiver pairs will be randomly assigned to the ROCKS program or usual car…

This study looks at whether two different exercise programs can help reduce depression in people with multiple sclerosis (MS) who also have major depressive disorder. Researchers will enroll 146 adults aged 18 to 64. One group will do a structured exercise program, while the othe…

This study tests whether rinsing the sinuses with a probiotic (good bacteria) solution can reduce symptoms of chronic sinusitis better than a plain saltwater rinse. About 60 adults who have had sinus surgery in the past will use the rinse daily for a period and report changes in …

This study is testing whether a device that sends small electrical pulses to leg muscles can help people with chronic stroke improve their balance and walking. Twenty participants will be exposed to slip- and trip-like disturbances on a treadmill, with and without the stimulation…

This pilot study tests a 12-week mindful walking program for older South Asian family caregivers (age 45+) who feel stressed and care for someone with cognitive disabilities. Fifty participants will be split into two groups: one does mindful walking with a Fitbit and motivational…

This study tests whether time-restricted eating (eating all food within an 8-hour window each day) is feasible and helpful for women undergoing chemotherapy for early-stage breast cancer. Forty participants will either follow this eating pattern or a usual diet for 24 weeks. Rese…

This study tests whether taking 3 mg of melatonin each night for 8 weeks can improve sleep and daily body rhythms in people with diabetic retinopathy. Researchers will track sleep patterns and hormone levels in 42 adults aged 40-65 with type 2 diabetes and moderate eye damage. Th…

This study looks at whether following a Mediterranean diet can help reduce chronic pain in people with sickle cell disease. About 30 adults with sickle cell disease who have pain most days will try the diet and report their pain levels. Researchers will also check changes in gut …

This study tests whether a smartphone-based mindfulness program is practical and liked by teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use a guided meditation app for about 8 weeks. The goal is to see if people…

This study is testing whether using mobile health apps and receiving tailored text messages can help people with chronic heart failure take better care of themselves and avoid hospital stays. Researchers will enroll 360 adults with Stage C heart failure and randomly assign them t…

This study tests a home-based balance training program for people with multiple sclerosis (MS). The program combines stepping games, strength, and thinking tasks. Researchers will compare it to a simple stretching routine in 75 adults with MS to see if it improves physical functi…

This study tests whether cognitive behavioral therapy for insomnia (CBTi) can improve sleep, blood sugar levels, and quality of life in adults with type 1 diabetes. Fifteen participants will either receive 8 virtual CBTi sessions or health education emails and calls over 12 weeks…

This study looks at whether using a blood pressure cuff on the thigh can make leg muscles stronger and improve walking in people who have lost a leg above the knee. Researchers will measure strength, walking ability, and daily activity before and after the intervention. The goal …

This study tests a technique called ischemic preconditioning, where blood flow to one thigh is briefly and repeatedly restricted using a device. Over two weeks, 24 adults with knee osteoarthritis and low back pain will receive either the full treatment or a sham (low pressure) ve…

This study tests whether a granisetron skin patch works better than ondansetron pills for preventing nausea and vomiting in people getting chemotherapy before a stem cell transplant. About 90 patients will be enrolled and randomly assigned to one of the two treatments. The goal i…

This study looks at whether eating only during an 8-hour window each day (time-restricted eating) can help women with breast cancer feel better and have fewer side effects during chemotherapy. Some participants will also follow a Mediterranean diet. The goal is to see if these ea…

This study tests whether a program that combines gentle walking with progressive muscle relaxation can help reduce the extreme tiredness (fatigue) that many people with end-stage kidney disease feel while on dialysis. Researchers will enroll 40 adults who are on hemodialysis and …

This study is testing whether a focused muscle contraction exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans. Twenty-five veterans with pain, fatigue, or low energy will do 90 exercise sessions over 18 …

This study tests whether using a home-based electrical stimulation device, combined with specific exercises, can help people with chronic stroke improve their walking, balance, and mobility. Thirty adults who had a stroke more than six months ago will use the device during traini…

This study tests a program called Healthy ReStart that uses health coaching, motivational interviewing, and online tools to help adults with serious mental illness return to active lives after major disruptions like the COVID-19 pandemic. Sixty participants will receive either th…

This study tests whether virtual reality dance games, like 'Just Dance', can help people who have had a stroke improve their balance and movement. Researchers will compare this fun, home-friendly approach to standard physical therapy. The goal is to see if it's safe, enjoyable, a…

This study is testing whether personalized text messages can help older adults (age 50+) with heart failure improve their self-care, like taking medications correctly and following a heart-healthy diet. Thirty participants will be split into two groups: one gets usual care plus t…

This study looks at how improving sleep regularity might help control blood sugar and reduce heart disease risk in adults with type 1 diabetes. Researchers will monitor 100 participants' sleep, blood sugar, and heart health markers. The goal is to understand the body clock's role…

This study is testing whether a low dose of the drug azacitidine, given before surgery, can increase immune cells (called tumor-infiltrating lymphocytes) in the tumors of people with high-risk early-stage breast cancer. About 40 participants will receive the drug for a short time…

This study explores whether exercising the unaffected leg at home can trigger beneficial brain and spinal changes in people with severe stroke. Participants perform strength and coordination tasks with their stronger leg using a tablet-based system, while researchers measure brai…

This trial investigates whether a lidocaine infusion given during pancreatic cancer surgery can affect circulating tumor cells (CTCs) — cancer cells that may travel through the blood. Researchers will compare lidocaine to a saline placebo in patients undergoing robotic pancreatec…

This study tests a 6-month program called PROTECT for caregivers of young children who need dental surgery. The program provides parenting tools and support from community health workers to improve tooth brushing and reduce added sugar intake. The goal is to prevent future caviti…

This study tests a method where people newly diagnosed with HIV are asked to recruit anyone they know who might benefit from HIV testing. The goal is to find more undiagnosed cases, especially among men who often avoid testing due to stigma. About 2,480 participants from 32 clini…

This study tests whether three short phone coaching sessions can help Latina women at high risk for breast cancer get the screening and genetic services they need. Researchers will enroll 600 Latina women with genetic and social risk factors. Half will get the coaching, and the o…

This study is testing a new way to reduce opioid overdoses on Chicago's West Side. Researchers will train friends and family members of people who use opioids to become harm reduction champions. These champions will learn about tools like naloxone and fentanyl test strips, and th…

This study is creating a digital program to help East Asian immigrants with cancer build resilience and start conversations about advance care planning with their families. Researchers will interview religious leaders and test the tool with 84 patients to see if it is easy to use…

This study compares two methods of offering cancer genetic testing to patients in community health centers. One method lets primary care doctors order tests directly, while the other uses a specialist model with extra support. Researchers will track how many patients get tested a…

This study looks at why people who have had a stroke often have trouble coordinating their legs when walking. Researchers will measure brain and nerve signals in 50 participants to find out what causes these coordination problems. They will also test if a mild electrical stimulat…

This study tests if analyzing waste from surgical suction devices can help detect brain tumor cells during surgery. About 8 adults with suspected high-grade gliomas or other brain tumors will take part. The goal is to see if this method improves tumor removal compared to standard…

This study is testing a program called Coffee and Family Education and Support (CAFES2) for refugee families from Arabic-speaking countries who have recently moved to Chicago. The program is led by trained peers and aims to improve mental health and family relationships. Research…

This study collects tissues and MRI scans from 40 adults with ALS to find markers of disease progression. Researchers will compare imaging and genetic data from spinal cord and brain areas. The goal is to better understand ALS and guide future research.

This study looks at how 12 weeks of aerobic exercise changes DNA methylation—a chemical tag on genes—in fat tissue of 80 people with obesity who are scheduled for bariatric surgery. Researchers want to see if these changes improve blood vessel function and reduce inflammation. Th…