New strategy aims to keep breast cancer patients on Full-Dose targeted therapy
NCT ID NCT06169371
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether slowly increasing the dose of the drug abemaciclib over three weeks helps patients with early-stage HR+HER2- breast cancer stay on the full approved dose. About 50 participants will receive the drug alongside hormone therapy. The main goal is to see if more patients can tolerate the full dose after 84 days, while tracking side effects like diarrhea.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Abemaciclib (a targeted cancer drug taken as pills)
What this could lead to
If successful, this approach could help more patients tolerate the full dose of abemaciclib, potentially improving cancer control and reducing recurrence risk.
What could go wrong
This is a small, single-arm phase 4 trial with only 50 participants, so results may not apply broadly. Side effects like diarrhea are common and could still limit dose escalation.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Iowa Holden Comprehensive Cancer Center
RECRUITINGIowa City, Iowa, 52242, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Illinois
RECRUITINGChicago, Illinois, 60612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••