Implanted electrical system aims to restore movement in paralyzed limbs

NCT ID NCT00623389

Recruiting now Disease control Sponsor: Case Western Reserve University Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants will receive the implant and undergo physical therapy, with researchers measuring how long they can stand and how far they can walk over a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Implanted Stimulator-Telemeter (IST) device with functional electrical stimulation
What this could lead to: If successful, this implanted system could help people with paralysis stand, walk short distances, and improve daily function without relying on caregivers.
What could go wrong: This is a very small early-stage trial with only 10 participants. The device requires surgery and may not work for everyone. Risks include infection, device failure, or no improvement in function.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis nervous system disorder palsy paraplegia quadriplegia Rare Diseases spinal cord injury stroke disorder traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARALYSIS PARAPLEGIA SPINAL CORD INJURIES STROKE TETRAPLEGIA

Contacts and locations

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Locations

Louis Stokes Cleveland VA Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States

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MetroHealth System
RECRUITING

Cleveland, Ohio, 44109, United States

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