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Could a stomach acid blocker shield stroke patients from bleeding?

NCT ID NCT07687706

Recruiting now Disease control Sponsor: Hanyang University Guri Hospital Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether tegoprazan, a stomach acid blocker, can prevent gastrointestinal complications like bleeding and ulcers in people who have had an ischemic stroke and are taking antiplatelet drugs (blood thinners). About 1,500 adults in South Korea will receive either tegoprazan or a placebo daily for 180 days, and their stomachs will be examined with a camera at the end. The goal is to provide the first solid evidence on whether routine stomach protection is beneficial in stroke care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Tegoprazan
What this could lead to
If successful, this could establish a standard way to protect the stomach in stroke patients on blood thinners, reducing serious bleeding complications.
What could go wrong
This is a single-country trial, and results may not apply to all populations. The drug may not reduce complications enough to justify routine use, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

cerebrovascular disorder Gastrointestinal Hemorrhage ischemic stroke transient ischemic attack duodenal ulcer prevention target gastric ulcer prevention target peptic esophagitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CEREBROVASCULAR DISEASE GASTROINTESTINAL BLEEDING GASTROINTESTINAL COMPLICATION ISCHEMIC STROKE ISCHEMIC STROKE, ACUTE TRANSIENT ISCHEMIC ATTACK (TIA)

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Asan Medical Center

    RECRUITING

    Seoul, South Korea

  • Chonnam National University Hospital

    RECRUITING

    Gwangju, South Korea

  • Chungbuk National University Hospital

    RECRUITING

    Cheongju-si, North Chungcheong, South Korea

  • Dong-A University Hospital

    RECRUITING

    Busan, South Korea

  • Ewha Womans University Seoul Hospital

    RECRUITING

    Seoul, South Korea

  • Gangnam Severance Hospital

    RECRUITING

    Seoul, South Korea

  • Hallym University Chuncheon Sacred Heart Hospital

    RECRUITING

    Chuncheon, Gangwon-do, South Korea

  • Hallym University Sacred Heart Hospital

    RECRUITING

    Anyang-si, Gyeonggi-do, South Korea

  • Hanyang University Guri Hospital

    RECRUITING

    Guri-si, South Korea

    Contact Email: •••••@•••••

  • Hanyang University Hospital

    RECRUITING

    Seoul, South Korea

  • Jeonbuk National University Hospital

    RECRUITING

    Jeonju, Jeollabuk-do, South Korea

  • Kangdong Sacred Heart Hospital

    RECRUITING

    Seoul, South Korea

  • Kangwon National University Hospital

    RECRUITING

    Chuncheon, Gangwon-do, South Korea

  • Keimyung University Dongsan Hospital

    RECRUITING

    Daegu, Daegu, South Korea

  • Korea University Anam Hospital

    RECRUITING

    Seoul, South Korea

  • Korea University Ansan Hospital

    RECRUITING

    Seoul, South Korea

  • Kyung Hee University Hospital

    RECRUITING

    Seoul, South Korea

  • Kyungpook National University Chilgok Hospital

    RECRUITING

    Daegu, South Korea

  • Pusan National University Hospital

    RECRUITING

    Busan, Busan, South Korea

  • Seoul Metropolitan Government-Seoul National University Boramae Medical Center

    RECRUITING

    Seoul, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, South Korea

  • Ulsan University Hospital

    RECRUITING

    Ulsan, South Korea

  • Wonkwang University Hospital

    RECRUITING

    Iksan, Jeollabuk-do, South Korea

  • Yeungnam University Medical Center

    RECRUITING

    Daegu, South Korea

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