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A simple breath test after a heart attack could prevent dangerous bleeding

NCT ID NCT05024864

Prevention Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether routinely screening heart attack patients for H. pylori, a common stomach bacteria, can prevent upper gastrointestinal bleeding. The bacteria can cause ulcers that bleed, especially when patients take blood thinners after a heart attack. Researchers will compare hospitals that offer the breath test to those that do not, and follow patients for several years. If screening works, it could become a standard step after a heart attack.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Urea breath test for H. pylori screening, followed by eradication therapy if positive
What this could lead to
If it works, routine H. pylori screening after a heart attack could become standard care, lowering the risk of serious stomach bleeding in these patients.
What could go wrong
The trial is large but relies on real-world registry data, and the benefit may be smaller than hoped. Eradication therapy also carries its own side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2021

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 * Registered in SWEDEHEART as discharged alive at a study site with a diagnosis of type 1 MI (including ICD-10 code I21 or I22). Exclusion Criteria: * None

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction cardiovascular disorder Gastrointestinal Hemorrhage Helicobacter pylori infectious disease myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Gastrointestinal bleeding Helicobacter pylori infection Myocardial infarction

Contacts and locations

Locations

  • Danderyds University Hospital

    Stockholm, Sweden

  • Eskilstuna Hospital

    Eskilstuna, Sweden

  • Falun Hospital

    Falun, Sweden

  • Gävle Hospital

    Gävle, Sweden

  • Halmstad Hospital

    Halmstad, Sweden

  • Helsingborg Hospital

    Helsingborg, Sweden

  • Karlskrona Hospital

    Karlskrona, Sweden

  • Karolinska University Hospital Huddinge

    Stockholm, Sweden

  • Karolinska University Hospital Solna

    Stockholm, Sweden

  • Kristianstad Hospital

    Kristianstad, Sweden

  • Kungälv Hospital

    Kungälv, Sweden

  • Köping Hospital

    Köping, Sweden

  • Lidköping Hospital

    Lidköping, Sweden

  • Linköping University Hospital

    Linköping, Sweden

  • Mora Hospital

    Mora, Sweden

  • Motala Hospital

    Motala, Sweden

  • Mölndal Hospital

    Mölndal, Sweden

  • Norra Älvsborgs Länssjukhus

    Trollhättan, Sweden

  • Norrland University Hospital

    Umeå, Sweden

  • Norrtälje Hospital

    Norrtälje, Sweden

  • Nyköping Hospital

    Nyköping, Sweden

  • Ryhov Hospital

    Jönköping, Sweden

  • Sahlgrenska University Hospital

    Gothenburg, Sweden

  • Sankt Görans Hospital

    Stockholm, Sweden

  • Skåne University Hospital Lund

    Lund, Sweden

  • Skåne University Hospital Malmö

    Malmö, Sweden

  • Sunderby Hospital

    Södra Sunderbyn, Sweden

  • Södersjukhuset

    Stockholm, Sweden

  • Södra Älvsborg Hospital

    Borås, Sweden

  • Uppsala University Hospital

    Uppsala, Sweden

  • Varberg Hospital

    Varberg, Sweden

  • Vrinnevisjukhuset

    Norrköping, Sweden

  • Västerås Hospital

    Västerås, Sweden

  • Örebro University Hospital

    Örebro, Sweden

  • Östra Hospital

    Gothenburg, Sweden

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