Karolinska Institutet

This study is testing whether a special powder containing tiny amounts of common food allergens can cure food allergies in very young children. It will involve 80 children, aged 6 months to 3 years, who are allergic to foods like milk, egg, or peanut. Half will receive the active…

This study is testing whether letting patients with severe mental health conditions admit themselves to the hospital when needed works better than the current system where doctors make all admission decisions. Researchers will follow 564 patients in Stockholm who can use this sel…

This study is testing a lifestyle program designed to help adults with obsessive-compulsive disorder (OCD) become more active and improve their heart health. Researchers will compare the program to standard medical and lifestyle advice to see which is more effective and cost-effe…

This study tests if starting cooling treatment immediately at the scene of a cardiac arrest, using a special nasal device, helps people survive with better brain function. It compares this early cooling approach to the current standard of care, which maintains normal body tempera…

This study aims to find the best first step for women with advanced endometriosis who want to get pregnant. It will compare two common approaches: having surgery to remove endometriosis tissue before starting IVF fertility treatment, or starting IVF treatment right away. The main…

This study aims to find the best way to treat nerve injuries in the fingers. Researchers will randomly assign 166 adults with a cut finger nerve to either have surgery to stitch the nerve or to wear a cast without surgery. The main goal is to see which treatment better restores t…

This study is comparing two methods for giving a lung medicine called surfactant to premature babies with breathing difficulties. The goal is to see if a newer, gentler method using a soft mask in the throat works as well as the standard method that requires placing a breathing t…

This study aims to find out which of two gentle drilling methods works better for treating deep cavities in the permanent teeth of children and teens aged 8-19. It will compare a one-visit procedure with a two-visit procedure to see which one better preserves the life of the toot…

This study is testing if a newer type of talk therapy, called transdiagnostic Metacognitive Therapy (tMCT), works better than the current standard therapy, Cognitive-Behavioral Therapy (CBT), for adults with anxiety disorders. It will involve 86 people in Sweden diagnosed with Ge…

This study is testing if a heart failure drug called eplerenone is safe and might help people who have both weak hearts and severe kidney disease. Doctors are enrolling 40 patients who have been excluded from past trials due to safety concerns about their kidneys. The main goal i…

This study aims to see if surgery to repair a leaky, floppy mitral heart valve can reduce dangerous irregular heartbeats and heart scarring in patients who have both conditions. Researchers will follow 90 patients needing this standard surgery, checking their heart rhythms and pe…

This study is testing whether adding a supervised exercise program to standard chemotherapy before breast cancer surgery can help eliminate tumors more completely. It will involve 712 patients who will either follow a high-intensity exercise plan during their chemo or receive usu…

This study aims to find out if simple movement therapy works as well as surgery for certain broken hand bones. It will enroll 552 adults with displaced spiral fractures in their fingers. Participants will be randomly assigned to either have surgery with screws/plates or to skip s…

This study investigates whether letting patients with generalized anxiety disorder choose between two types of online therapy leads to better outcomes than having a treatment randomly assigned. It also tests if a psychologist's prediction about which treatment will work best for …

This study is testing whether adding a digital support system called Evira helps children and teens with obesity manage their weight better. Evira includes a special scale for daily weigh-ins at home and a mobile app that lets parents and healthcare providers track progress and m…

This study aims to find out which of two common surgical techniques works better for repairing a torn ACL knee ligament in active athletes. Researchers will compare using a hamstring tendon versus a quadriceps tendon graft. They will measure knee stability, recovery, pain, and ho…

This study is testing whether performing a second kidney biopsy one year after starting treatment helps people with lupus nephritis. About 206 adults with a first episode of lupus-related kidney inflammation will be randomly assigned to either get this follow-up biopsy or receive…

This study is testing a new, faster way to treat PTSD in teenagers. It packs therapy, exercise, and parent support into a 5-day intensive program, instead of weekly sessions over many months. The goal is to see if this condensed approach is practical, acceptable to therapists and…

This study is testing whether a natural compound in beetroot juice can help patients with a serious type of lung blood clot. The clot causes high pressure in the lungs, putting dangerous strain on the heart. Researchers want to see if the beetroot juice safely relaxes lung blood …

This study is testing a new approach to personalize tuberculosis (TB) treatment. It aims to see if using computer models can help doctors adjust a patient's drug doses more quickly and accurately during the early phase of treatment. The goal is to ensure patients get the right am…

This study aims to see if adding short daily stair climbing to regular brisk walking lowers high blood pressure more effectively than walking alone in inactive adults who are overweight and have hypertension. It will involve 450 participants split into three groups: one combining…

This study is testing an online therapy program designed to help teens who engage in self-harm without suicidal intent. It aims to see if the program is practical to use and if it can help reduce self-injury. The program focuses on teaching teens better ways to manage their emoti…

This study aims to see if replacing the arthritic thumb joint with an artificial implant provides better long-term pain relief and hand strength than the standard surgery that removes bone. Researchers will follow 90 patients who get the new joint replacement and compare their re…

This study is testing a new blended therapy for post-traumatic stress disorder (PTSD) that combines online computer modules with in-person therapy sessions. Researchers want to see if this new approach works as well as the current gold standard therapy, called Prolonged Exposure.…

This study is testing a new family-based therapy program called SAFETY, designed to prevent teens from attempting suicide again. It will compare SAFETY to standard enhanced care in 282 young people aged 10-17 who have recently attempted suicide. The goal is to see if the SAFETY p…

This study is testing two ways to get students to eat more fruit at school. Researchers are placing free fruit stands in schools; some schools get just the stands, while others also get a health-awareness campaign. About 300 Swedish students, aged 7 to 19, will use a phone app to…

This study is testing whether a simple, at-home self-sampling kit for HPV (the virus that causes cervical cancer) can provide effective screening for women in Ukraine during the ongoing war. It aims to offer 1,000 women aged 30-60 a convenient way to get tested when regular clini…

This study is testing whether an online therapy program can help people who have had a heart attack manage their anxiety about their heart health. Researchers will compare an online cognitive behavioral therapy (CBT) program designed for this specific anxiety to a general online …

This study is testing an online therapy program called POET that helps teens (ages 12-17) learn to manage their emotions and improve mental health. Researchers will compare this digital program, which includes therapist support through online modules and video sessions, to standa…

This study is testing an online therapy program to help children aged 8-17 who have chronic functional abdominal pain. Researchers want to understand how children's brains and bodies process pain and whether this online therapy can reduce their symptoms and improve their daily li…

This study looks back at medical records to see if using a specific nerve block during cleft palate surgery helps children after their operation. Researchers want to know if this block reduces the need for strong painkillers like morphine and helps kids go home from the hospital …

This study is testing whether a new feedback system helps social services work better for people. The system asks clients regularly how their support is going and what they think about it. Researchers will compare usual care to care using this feedback method for 400 people deali…

This study is testing whether a specific type of group therapy, called Metacognitive Therapy (MCT), is practical and acceptable for treating PTSD in a regular Swedish psychiatric clinic. It will involve about 30 adults with PTSD to see if they can complete the 14-week program and…

This study is testing whether a specially designed mobile app can improve mental wellbeing for pregnant women. About 440 participants will be randomly assigned to use either the new mental health app or a standard health app. Researchers will measure changes in resilience, stress…

This study is testing a new therapy program designed to help people with long-term, disabling fatigue. It will compare a special type of talk therapy (tCBT) delivered partly online and partly in person to the usual care patients receive from their doctor. Researchers want to see …

This study is testing whether an internet-based cognitive behavioral therapy (iCBT) program can help adults with ADHD. Two hundred participants in Sweden will be randomly assigned to either receive the 10-week online therapy program immediately or be placed on a waitlist. The mai…

This study is testing whether patients recover just as well—or better—when they go home the same day of their robotic hysterectomy surgery compared to staying overnight in the hospital. It will involve 300 patients with both benign conditions and early-stage endometrial cancer. R…

This study is testing a 10-week online therapy program designed specifically for Farsi/Dari-speaking young migrants and refugees. It aims to help reduce symptoms of anxiety, depression, grief, and stress. Participants will be randomly assigned to either receive the therapy immedi…

This study is testing a 10-week online psychological treatment program for cancer survivors who are struggling with anxiety, depression, or fear of their cancer returning. It will enroll 400 survivors in Sweden to figure out which parts of the online therapy are most helpful. The…

This study is testing two online psychological treatments to help children and teenagers manage chronic stomach pain caused by gut-brain communication problems. Researchers are comparing internet-based cognitive behavioral therapy (iCBT) with gut-directed hypnotherapy delivered t…

This small pilot study is testing whether adding yoga-based exercises to standard medical care can help people with severe, frequent migraines or cluster headaches. It will enroll 40 adults to try either online or in-person yoga sessions. The main goal is to see if this approach …

This study aims to understand if children with a tracheostomy tube (a breathing tube in the neck) who have trouble eating or swallowing also report a lower quality of life. Researchers will observe 80 children and their parents, using questionnaires to measure quality of life and…

This study aims to find out if adjusting workout schedules based on a woman's menstrual cycle improves fitness and performance. It will involve 111 healthy, active women with regular cycles who will follow different training plans for 12 weeks. Researchers will measure changes in…

This study aims to understand how common severe anesthesia complications are when children with a tracheostomy tube have routine airway check-ups. Researchers will observe up to 80 children under 18 during their scheduled procedures to see if complications occur and if certain pa…

This study aims to understand how immune cells behave in people with diabetes who have chronic foot ulcers that won't heal. Researchers will compare blood and tissue samples from 40 patients whose ulcers are healing versus those whose ulcers are not healing. The goal is to identi…

This study aims to understand if the benefits of jaw joint (TMJ) surgery last over the long term. Researchers are following 91 patients who had surgery about 10 years ago to see if their positive results at the 6-month check-up have held up. The goal is to learn if early success …

This international study aims to understand how weight loss affects body image and self-perception in people with advanced cancer. Researchers will survey 800 patients across eight countries to learn about their experiences with weight changes, appetite, and body image concerns. …

This study aims to understand how the bacteria in our gut and mouth are connected to epilepsy and might influence how well seizure medications work. Researchers will collect samples from 1,500 people, including those newly diagnosed with epilepsy and healthy volunteers, to look f…

This study aims to understand how having COVID-19 affects recovery after surgery. Researchers will compare 300,000 surgical patients in Stockholm, looking at those with and without COVID-19. They'll track outcomes like hospital stays, complications, and recovery to help doctors p…

This study aims to understand how often serious airway problems in children with tracheostomies show no symptoms. Researchers will check if reports from parents or pediatricians can reliably predict these complications found during routine scopes. The goal is to see if future mon…

This study aims to find out if a special training program for doctors (called Advanced Trauma Life Support® or ATLS®) leads to better survival rates for injured patients compared to the standard emergency care doctors already provide. It will involve over 4,300 adult patients arr…

This study aims to see if brain scans can better predict how well a person will respond to online therapy for depression, social anxiety, or insomnia, compared to just asking them. Researchers will scan the brains of 150 people before they start a 12-week online therapy program. …

This study aims to find out if safely reducing unnecessary blood tests and x-rays in intensive care units (ICUs) affects patient survival. It will involve 10,000 adult patients across Sweden's ICUs. Researchers will compare standard care to a new approach that questions the need …

This study aims to find objective, physical evidence in the brain that explains how an internet-based therapy helps people with fibromyalgia. Researchers will measure pain sensitivity and processing in 50 participants before and after they complete a 10-week online cognitive beha…

This study aims to understand why people with type 2 diabetes have a higher risk of heart attacks. Researchers will collect red blood cells from 500 people—including those with diabetes, those who have had a heart attack, and healthy individuals—to test how these cells function i…

This study aims to find better ways to monitor the effectiveness of treatments for hemophilia patients who have developed inhibitors, which make standard treatments less effective. Researchers will test new blood analysis methods on 20 patients over two years to see if these test…

This study aims to see if people who are more physically active before surgery have fewer complications and recover better. Researchers will observe 264 adults having non-emergency surgery, using step count data from their mobile phones to measure activity. The goal is to learn i…