Blood test may replace painful heart biopsies for transplant patients

NCT ID NCT07531784

Recruiting now Diagnosis Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a blood test that measures donor DNA can detect rejection in heart transplant patients. Researchers will compare the test results with standard heart biopsies in 120 adults across Sweden. If the test works well, it could offer a less invasive way to monitor for rejection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: donor-derived cell-free DNA blood test
What this could lead to: If successful, this blood test could replace some invasive heart biopsies, making rejection monitoring safer and easier for transplant patients.
What could go wrong: This is an observational study, not a treatment trial. The test may not be accurate enough to replace biopsies, and results may vary between patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART TRANSPLANT REJECTION HEART TRANSPLANTATION

Contacts and locations

Locations

Karolinska University Hospital
RECRUITING

Stockholm, Sweden

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