Heart transplant monitoring may go needle-free with new MRI technique

NCT ID NCT05521399

Recruiting now Diagnosis Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study explores whether a special cardiac MRI can detect complications after heart transplantation without the need for invasive biopsies or angiography. Researchers will scan 247 adults and children, including healthy volunteers and transplant recipients, to see if MRI measures of heart tissue and function can predict rejection and blood vessel damage. If it works, it could make monitoring safer, cheaper, and more comfortable for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cardiac MRI (diagnostic test)
What this could lead to: If successful, this could replace painful, risky biopsies and angiograms with a simple, non-invasive MRI scan for heart transplant patients.
What could go wrong: This is an observational study, not a treatment trial. The MRI technique is still being refined, and it may not be accurate enough to fully replace current invasive tests.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAGNETIC RESONANCE IMAGING TRANSPLANT, HEART

Contacts and locations

Locations

Northwestern University- Feinberg School of Medicine
RECRUITING

Chicago, Illinois, 60611, United States
The Ann & Robert Lurie Children's Hospital
RECRUITING

Chicago, Illinois, 60611, United States

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