New study aims to spot heart transplant rejection without a biopsy

NCT ID NCT06774365

Recruiting now Knowledge-focused Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 683 heart transplant patients to see if advanced heart scans (CMR) and blood tests can detect antibody-mediated rejection, a common complication. Participants must be stable and at least one year post-transplant. The goal is to find non-invasive ways to diagnose rejection earlier and more accurately.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better, non-invasive ways to detect rejection in heart transplant patients, reducing the need for biopsies.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly improve outcomes. Results may not change current practices if imaging or biomarkers prove unreliable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART TRANSPLANTATION HLA ANTIGENS REJECTION HEART TRANSPLANT

Contacts and locations

Locations

ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, Milano, 20162, Italy
Azienda Ospedaliera Universitaria Consorziale Policlinico di Bari
NOT_YET_RECRUITING

Bari, Bari, 70120, Italy
Azienda Ospedaliera dei Colli
RECRUITING

Naples, Napoli, 80131, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna
RECRUITING

Bologna, Bologna, 40138, Italy

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