Irccs Azienda Ospedaliero-universitaria Di Bologna

This study tests whether a fecal microbiota transplant (FMT) can help liver cancer patients who stopped responding to standard drugs. Fifteen adults with advanced liver cancer will receive FMT along with atezolizumab and bevacizumab to see if the combination can restore tumor con…

This study tests a newer pacing method called Conduction System Pacing (CSP) against standard right ventricular pacing in 1,260 adults with heart block. The goal is to see if CSP reduces heart failure events, hospitalizations, and need for additional procedures, while also improv…

This study looks at two ways to trigger ovulation in women with cancer who are freezing their eggs before chemotherapy. One method uses a GnRH agonist alone, the other combines it with hCG (dual trigger). The goal is to see which approach retrieves more eggs while reducing the ri…

This study looks at three forms of levothyroxine (a thyroid hormone medicine) given to babies diagnosed with congenital hypothyroidism. Researchers will compare a new oral solution to standard liquid drops and tablets, checking how well they control hormone levels and affect deve…

This study tests whether a doctor-led counseling program, combined with two smartphone apps (Nutrida and Gamebus), can help older adults (60+) who have had a liver or kidney transplant eat better and be more active. Sixty participants will first receive lifestyle advice, then use…

This study looks at whether using a combination of antibiotics is more effective than a single drug for treating Enterococcus faecalis bloodstream infections. Researchers will also analyze the gut bacteria of 510 adult patients to see how it affects treatment success. The goal is…

This study tests a new navigation system called LungVision to help doctors mark suspicious lung nodules before surgery. The system uses augmented fluoroscopy and ultrasound to guide a small marker to the nodule. The goal is to make marking easier and less invasive than current me…

This study looks at 200 adults with inflammatory bowel disease (IBD) who are hospitalized due to worsening symptoms. Researchers want to see if testing blood or stool for CMV (a common virus) is as accurate as the standard method of testing a tissue sample from the colon. The goa…

This study is developing a computer program that can analyze heart sounds recorded with a digital stethoscope to tell if a newborn's heart is healthy or not. Researchers will record heart sounds from 1,000 babies under 30 days old and use those recordings to train and test the pr…

This study is testing whether a quick, non-invasive test of blood vessel function can help predict and diagnose preeclampsia and other high blood pressure disorders in pregnancy. Researchers will follow 400 first-time pregnant women, measuring vessel health early in pregnancy and…

This study tests a new way to do PET scans for men with high-risk prostate cancer. Instead of two full CT scans, it uses one CT plus a delayed PET-only image, which may lower radiation exposure. Researchers will check if the delayed images match the standard ones well enough. The…

This study explores whether genetic material from tiny particles called extracellular vesicles, collected during a bronchial lavage (a lung wash), can be used for advanced genetic testing in people with advanced lung cancer. The goal is to see if this less invasive method can pro…

This study tests whether a new device called Simeox, which uses gentle vibrations to loosen mucus without forced breathing, works better than standard chest physiotherapy for people with bronchiectasis. Forty adults with stable disease will try both methods in a crossover design.…

This study compares two ways to take a tissue sample from the lining of the uterus in menopausal women whose lining is thin (atrophic or hypotrophic). The 'chip biopsy' and 'rail biopsy' techniques are both used in practice, but it is not clear which is faster, safer, or provides…

This study tests whether showing first-time mothers real-time ultrasound images of their pelvic floor muscles can help them push more effectively during labor. The trial focuses on women at full-term pregnancy who have a specific muscle coordination issue. Participants receive ei…

This observational study will follow 10,000 adults with obesity or overweight to understand how the disease progresses and what factors predict treatment success. Researchers will analyze medical records from 2000 onward, looking at heart and metabolic complications over 5 to 10 …

This study compares severe respiratory infections in children with bronchopulmonary dysplasia (BPD) to those without BPD. Researchers will look back at past cases and follow new cases until 2030. The goal is to learn what makes these infections more dangerous for children with BP…

This study is collecting ultrasound measurements of the heart and carotid arteries from 1,400 healthy children aged 0-18 in Italy. The goal is to create a reference range of normal values, so doctors can better identify when something is abnormal. No treatment is being tested; it…

This study is looking at 100 adult patients who have had an organ or stem cell transplant and later developed a CMV infection that is resistant or hard to treat with standard antiviral drugs. Researchers want to find out how common this problem is and what factors make it more li…

This study is observing 200 patients who received a large leg implant (megaprosthesis) between 2020 and 2023. Researchers want to learn how many get infections, what puts them at risk, and how those infections turn out. The goal is to gather information, not to test a new treatme…

This observational study is looking at how two antibiotics, ceftazidime/avibactam and fosfomycin, work in the body to treat infections caused by carbapenem-resistant Enterobacterales (CRE), a type of superbug. Researchers will monitor 60 adult patients to see if the drug levels i…

This study aims to find tiny genetic markers (microRNAs) and blood chemicals that can tell doctors early whether a liver cancer patient will fully respond to heat-based tumor destruction. Researchers will analyze blood and tumor tissue samples from 150 adults with early-stage liv…

This study looks at 683 heart transplant patients to see if advanced heart scans (CMR) and blood tests can detect antibody-mediated rejection, a common complication. Participants must be stable and at least one year post-transplant. The goal is to find non-invasive ways to diagno…

This study is observing 400 adults with advanced heart failure who have received a continuous-flow ventricular assist device (VAD), a mechanical pump that helps the heart circulate blood. Researchers will track survival rates in the hospital and at one and five years after implan…

This study looks at data already collected from 600 multiple myeloma patients to find patterns linking genetics, imaging, and clinical outcomes. Researchers will use artificial intelligence to build models that might predict disease progression and treatment response. No new test…

This observational study is collecting genetic and clinical information from 520 people with multiple myeloma to better understand why the disease progresses or comes back. Researchers will analyze tumor DNA and RNA to find patterns linked to treatment response. The goal is to cr…

This study looks at two ways to help cancer patients preserve their fertility before treatments like chemotherapy. One group will freeze both ovarian tissue and eggs, while the other group will freeze only eggs. Researchers will compare how many eggs are retrieved in each group. …

This study looks at whether a new way of scoring whole-body MRI scans can reliably measure bone inflammation in children with CRMO, a rare condition causing repeated bone pain and swelling. Researchers will compare the MRI scores from different doctors and also check if changes i…

This study is tracking 100 people with early-stage lung cancer who had surgery. Researchers will measure tumor cells and DNA in their blood to see if these markers can predict if the cancer comes back. The goal is to better understand how lung cancer spreads and improve long-term…

This study follows children who had radiation therapy for cancer to see how often they develop thyroid nodules or thyroid cancer. Researchers will compare them to children who did not have radiation, looking for risk factors and genetic clues. The goal is to create better screeni…

This study looks at newborns who lose too much salt due to rare hormone problems that can be mistaken for a more common condition called congenital adrenal hyperplasia. Researchers want to find out how often these rare conditions happen and describe their symptoms, genetics, and …

This study is looking at the genes of 350 children born with permanent congenital hypothyroidism, even though their thyroid gland is in the right place. Researchers will use advanced genetic sequencing to find DNA changes that might explain the condition. The goal is to better un…

This study looks at how gut bacteria and the immune system interact in children and adults receiving stem cell transplants or CAR-T therapy. Researchers will collect stool and blood samples over time to find patterns linked to complications like infections or graft-versus-host di…

This study looks at cholesterol and blood sugar levels in 200 people with Noonan syndrome and related conditions, aged 2 to 35. Researchers want to see if these levels differ by age, gender, or genetic type. The goal is to improve long-term care by identifying who might be at hig…

This study aims to create a national map of cutaneous lymphoma cases in Italy, looking at how common these rare skin cancers are and where they occur. Researchers will review medical records from 1,000 patients across multiple hospitals, tracking age, sex, location, and possible …

This study follows 180 children in Italy born with biotinidase deficiency, a rare condition that can cause skin, eye, and nerve problems if untreated. Researchers will compare each child's genetic makeup with their enzyme activity levels and health outcomes. The goal is to better…

This study looks at 300 children with central precocious puberty (early puberty) to see how many also have a neurodevelopmental syndrome or condition. Researchers will compare the diagnosis and development of children with early puberty alone versus those with an associated brain…

This study is collecting information from 520 children and teens in Italy with 46, XY DSD, a rare condition where a person's chromosomes don't match their physical sex development. Researchers will look at medical records to understand how common different features are and how th…

This study follows 60 girls and women with classic galactosemia, a rare genetic condition that affects how the body processes sugar. Researchers want to understand why many develop early ovarian failure and how puberty progresses. By tracking hormone levels and growth, they hope …

This observational study follows 2000 adults with liver tumors who need surgery but have too little healthy liver left. Doctors use various techniques to make the liver grow before surgery. The study simply watches what happens in real practice—it does not test any new drug or tr…

This study looks at whether PSMA PET scans can predict how well advanced prostate cancer patients will respond to treatments like hormone therapy or chemotherapy. Researchers will scan 1300 patients before they start treatment and track their outcomes. The goal is to find imaging…

This study looks at 500 people who are offered prescription weight-loss drugs like Wegovy or Mounjaro. Researchers want to understand what makes someone accept or refuse these medications. They will also track those who start treatment for up to 5 years to see how well the drugs …

This study follows 25 people with COPD and high carbon dioxide levels who use a breathing machine at night. Researchers want to see if nighttime breathing problems can predict how well the machine works over 6 to 12 months. They will also check lung function, diaphragm health, an…

This study tests whether newer imaging techniques like special ultrasound and MRI can detect heart damage earlier in children, adolescents, and young adults who have had cancer treatment. Researchers will follow 400 participants to see how many develop heart problems. The goal is…

This study uses advanced heart MRI scans to look at blood flow patterns in people with different types of hypertrophic cardiomyopathy (thick heart muscle), including rare forms like Anderson-Fabry disease and cardiac amyloidosis. Researchers will also study first-degree relatives…

This study is collecting information from 11,000 people who have had a heart attack or heart muscle injury. Researchers want to learn more about these conditions to improve future treatment. The study does not test a new drug or procedure, but instead gathers data to better under…

This study is checking for antibiotic-resistant bacteria in the gut of 200 people who take PrEP (HIV prevention pills). Researchers will collect rectal swabs during routine STI testing and analyze the bacteria for resistance. The goal is to understand how common resistance is in …

This study aims to find biological markers (biomarkers) that can predict how well patients will respond to treatment for a serious complication called gut graft-versus-host disease (GvHD) after a stem cell transplant for blood cancer. Researchers will collect samples from 90 pati…

This study looks at rare lymphomas that are hard to tell apart under the microscope—some look like Hodgkin lymphoma but lack a key marker (PAX5), making them similar to another type called anaplastic large cell lymphoma (ALCL). Researchers will analyze tissue samples from 60 adul…

This study looks at a protein called LEF-1 in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Researchers want to see if measuring LEF-1 can help make a more accurate diagnosis and find new clues about the disease. They will study tissue sample…

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…

This study looks at DNA methylation patterns in brain, thyroid, and endometrial tumors. Researchers aim to better classify these cancers and find new markers for early diagnosis. The study will involve 180 participants and uses existing tumor samples.

This study looks at whether certain genetic markers can predict which young women (ages 18-38) with breast cancer or Hodgkin lymphoma are more likely to experience early menopause and infertility after chemotherapy. Researchers will analyze stored ovarian tissue from 50 patients …

This study is looking at whether certain substances from the placenta (called sFlt-1 and PlGF) can help doctors know if a baby is in trouble during labor. Researchers will check these markers in pregnant women and compare them to the baby's heart rate and health after birth. The …

This study looks at 30 infants (3-8 months old) having surgery for craniosynostosis, a condition where skull bones fuse too early. Researchers want to see if a new monitoring method (PRAM) can better track blood pressure and fluid loss than standard monitors. The goal is to impro…

This study will follow 500 transgender adults who have been on gender-affirming hormone therapy for at least a year. Researchers will measure changes in blood pressure, cholesterol, body composition, and other heart health markers. The goal is to understand the long-term cardiova…