Irccs Azienda Ospedaliero-universitaria Di Bologna

This study aims to find out which form of thyroid hormone medication works best and safest for babies born with an underactive thyroid gland. Researchers will follow about 120 children in Italy for several years, comparing a new liquid solution to older drop and tablet forms. The…

This nationwide Italian study is observing how well modern mechanical heart pumps (called VADs) work for adults with severe, medication-resistant heart failure. It will track over 400 patients to see how many survive in the hospital and at 1 and 5 years after getting the pump, wh…

This study is testing whether a doctor-led lifestyle counseling program, combined with two personalized smartphone apps, is practical and helpful for older adults who have received a liver or kidney transplant. Participants first receive 12 weeks of medical advice on healthy eati…

This study aims to find the best way to use two antibiotics, alone or together, to treat serious infections caused by bacteria that resist standard drugs. Researchers will observe 60 adult patients to see how drug levels in the blood relate to treatment success. The goal is to ga…

This study is testing if a fecal microbiota transplant (FMT) can help patients with advanced liver cancer whose disease got worse while on standard drug therapy. Participants will receive the FMT and then restart the same cancer drugs to see if their response improves. The main g…

This study aims to find the best way to treat serious bloodstream infections caused by the bacteria Enterococcus faecalis. Researchers will compare giving patients a single antibiotic versus a combination of antibiotics to see which leads to better recovery. They will also study …

This study is testing whether newer, more sensitive heart scans can detect heart damage caused by chemotherapy and other cancer treatments earlier in children, teens, and young adult cancer survivors. It will follow 400 young people who have had cancer treatment to see if these s…

This study is testing new ways to predict which pregnant women might develop high blood pressure disorders or preeclampsia, a serious pregnancy complication. Researchers will use simple, non-invasive tests to measure blood vessel health in 400 first-time mothers during their firs…

This study aims to see if measuring a protein called LEF-1 in tissue samples can help doctors more accurately diagnose and understand chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). Researchers will analyze samples from 350 patients who already have these…

This study is testing whether genetic information for advanced non-small cell lung cancer can be reliably obtained from a simple lung wash procedure instead of an invasive tissue biopsy. Researchers will collect fluid from a routine bronchoscopy and analyze tiny particles called …

This study is investigating whether simple blood tests that measure certain placental markers can help predict which babies might experience distress during labor. It involves 428 pregnant women and aims to see if these markers are linked to signs of fetal compromise seen on the …

This study is testing a new navigation system called LungVision to help doctors place tiny markers near suspicious lung spots during a bronchoscopy. The markers make it easier for surgeons to find and remove these spots with smaller, more precise cuts, aiming for an accurate diag…

This study is testing a modified imaging method for prostate cancer that could reduce radiation exposure. Researchers are comparing a standard two-scan approach against a new method that uses only one CT scan instead of two, while still capturing detailed images. The goal is to m…

This study aims to find out if a new device called Simeox works better than standard physiotherapy for clearing mucus from the lungs of adults with bronchiectasis. Forty participants will try both methods for four weeks each, and researchers will measure their breathing, sputum p…

This study aims to understand the genetic causes of a lifelong thyroid condition present from birth, called congenital hypothyroidism. Researchers will analyze the genes of about 350 children and young adults in Italy who have this condition. The goal is to learn which genetic ch…

This study aims to better understand a rare and confusing type of lymphoma that looks like Hodgkin's disease but lacks a key identifying marker (PAX5). Researchers will collect data from about 60 adult patients with this condition to look for patterns in how the cancer looks, its…

This study aims to find out if a special type of imaging scan, called a PSMA PET scan, can predict how well different drug treatments will work for men with advanced prostate cancer. Researchers will observe 1,300 patients over 9 years to see if measurements from the scan can for…

This study aims to understand how often early puberty occurs alongside neurodevelopmental conditions like autism or ADHD. Researchers will review medical records of 300 children treated for early puberty over the past decade. They will compare characteristics between children who…

This study aims to understand how air pollution causes serious diseases like lung cancer, COPD, and leukemia. Researchers will compare pollution levels found in the bodies of 300 non-smoking patients with these conditions to levels in healthy volunteers. The goal is to find new b…

This study aims to learn how to better predict which COPD patients with high carbon dioxide levels will respond well to long-term nighttime breathing support (non-invasive ventilation). Researchers will observe 25 patients for one year, collecting data on their breathing patterns…

This study aims to understand how long-term gender-affirming hormone therapy affects heart health. Researchers will follow 500 transgender adults for at least a year, measuring blood pressure, cholesterol, body composition, and other health markers. The goal is to gather better s…

This study aims to create the first national map of how common skin lymphomas are in Italy. Researchers will collect data from about 1,000 patients to see if certain areas have more cases and to check for possible links to environmental factors like pollution. The goal is to bett…

This study aims to understand and describe how Italian hospitals use different techniques to make a patient's healthy liver tissue grow larger before surgery to remove liver tumors. It will observe 2,000 adult patients with liver cancer or other tumors who need this preparatory t…

This study aims to see if a new scoring system for whole-body MRI scans can reliably measure bone inflammation in children with Chronic Recurrent Multifocal Osteomyelitis (CRMO), a rare inflammatory bone disease. Researchers will check if different radiologists get similar result…

This study aims to improve how doctors tell apart different diseases that cause the heart muscle to thicken. Researchers will use detailed heart scans to look at blood flow patterns in 250 patients and their family members. The goal is to find unique 'fingerprints' for each disea…

This study aims to better understand biotinidase deficiency, a rare inherited disorder, in children identified through newborn screening in Italy. Researchers will follow about 180 children for at least three years to see how their specific genetic changes relate to their symptom…

This study aims to better understand heart and blood pressure changes during surgery to correct a skull condition in infants. Researchers will compare a newer, more detailed monitoring system against standard equipment in 30 babies aged 3-8 months. The goal is to gather knowledge…

This study aims to better understand how classic galactosemia affects puberty and ovarian function in girls. Researchers will observe 60 Italian girls with the condition, tracking their growth, hormone levels, and development. The goal is to identify factors linked to early ovari…

This study aims to find biological markers that can predict how severe a gut complication will be after a blood cancer transplant. Researchers will collect data from 90 patients to build a tool that helps doctors personalize treatment. The goal is to improve outcomes by identifyi…

This study aims to understand which patients accept a prescription for weight-loss drugs and why. It will follow 500 people aged 12 and older for up to 5 years to see how well the medications work and how long people stick with them in everyday life. The goal is to gather real-wo…

This study aims to gather detailed information about children and adolescents diagnosed with 46,XY DSD, a rare condition where a person's chromosomes, internal reproductive organs, and physical appearance develop in a disharmonious way. Researchers will collect and analyze medica…

This study aims to understand how the community of bacteria in the gut (the microbiome) affects recovery in children and adults receiving a bone marrow transplant or advanced cell therapy like CAR-T. Researchers will collect stool and blood samples from 260 patients over time to …

This study aims to learn if tiny cancer cells or DNA fragments found in the blood after lung cancer surgery can predict if the cancer will come back. Researchers will observe 100 patients who have had surgery for early-stage lung cancer. They will collect blood samples and analyz…

This study aims to better understand heart attacks and heart injuries by collecting detailed information from 11,000 patients. Researchers will observe which treatments patients receive and track their long-term health outcomes. The goal is to gather knowledge to potentially impr…

This study aims to understand if antibiotic-resistant bacteria are present in the gut of people taking medication to prevent HIV (PrEP). Researchers will analyze samples from 200 participants during their regular check-ups, looking for resistant bacteria. The goal is to gather in…

This study aims to understand why some young women develop early menopause after chemotherapy for breast cancer or lymphoma, while others do not. Researchers will analyze stored ovarian tissue from 50 patients to look for genetic differences between the two groups. The goal is to…

This study aims to find the best way to monitor children who had radiation therapy for cancer, as they have a higher risk of developing thyroid problems later. It will follow over 2,500 participants to see how often thyroid nodules or cancer occur, identify risk factors, and stud…

This study aims to analyze specific DNA patterns, called methylation, in tumor tissue from 180 patients with brain, uterine, or endocrine cancers. The goal is to understand how these patterns relate to different tumor types and patient outcomes. Researchers hope this information …

Neonatal salt loss can be caused not only by infections but also by rare endocrine disorders that resemble 21-hydroxylase deficiency but are not detected by neonatal screening. This study examines how often these conditions occur and describes their main clinical, genetic, and tr…