DNA detective work: why some babies have lifelong thyroid problems

NCT ID NCT06728735

Recruiting now Knowledge-focused Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is looking at the genes of 350 children born with permanent congenital hypothyroidism, even though their thyroid gland is in the right place. Researchers will use advanced genetic sequencing to find DNA changes that might explain the condition. The goal is to better understand the underlying causes, which could improve diagnosis and care in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors better understand the genetic causes of congenital hypothyroidism, potentially leading to earlier diagnosis or personalized treatment in the future.
What could go wrong: This is an early, observational study that does not test any treatment. It only looks at genetic data, so it may not directly change patient care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congenital hypothyroidism permanent congenital hypothyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HYPOTHYROIDISM

Contacts and locations

Locations

IRCCS Azienda Ospedaliero-Universitaria di Bologna
RECRUITING

Bologna, Bologna, 40138, Italy

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