Could a lung wash replace needle biopsies for cancer gene tests?

NCT ID NCT07188480

Recruiting now Diagnosis Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study explores whether genetic material from tiny particles called extracellular vesicles, collected during a bronchial lavage (a lung wash), can be used for advanced genetic testing in people with advanced lung cancer. The goal is to see if this less invasive method can provide the same genetic information as traditional tissue biopsies. If it works, it could reduce the need for repeated, risky biopsies to guide treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bronchial lavage for NGS analysis
What this could lead to: If successful, this could offer a less invasive way to get genetic information from lung tumors, helping doctors choose targeted therapies without repeated biopsies.
What could go wrong: This is a very small, early feasibility study with only 10 participants. It may not work in all patients, and the method needs to be validated against standard biopsy results.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER (NSCLC)

Contacts and locations

Locations

IRCCS Azienda Ospedaliero-Universitaria di Bologna
RECRUITING

Bologna, Bologna, 40138, Italy

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